148200-69-5Relevant academic research and scientific papers
β-Peptido sulfonamides: For-Met-Leu-Phe-OMe analogues containing taurine and chiral β-amino-ethanesulfonic acid residues
Giordano, Cesare,Nalli, Marianna,Paradisi, Mario Paglialunga,Sansone, Anna,Lucente, Gino,Spisani, Susanna
, p. 953 - 963 (2007/10/03)
A series of new β-peptido sulfonamides, related to the chemotactic tripeptide fMLF-OMe, has been synthesized. The examined 1a,b-7a,b models contain the achiral -HN-(CH2)2-SO2- taurine (Tau) residue or the chiral -HN-CH(nBu
Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin
De Bont, Dries B.A.,Dijkstra, Gerard D.H.,Den Hartog, Jack A.J.,Liskamp, Rob M.J.
, p. 3035 - 3040 (2007/10/03)
Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.
Synthesis of peptides containing a sulfinamide or a sulfonamide transition-state isostere
Moree, Wilna J.,Van Gent, Liesbeth C.,Van Der Marel, Gijs A.,Liskamp, Rob M. J.
, p. 1133 - 1150 (2007/10/02)
A versatile synthesis of peptides incorporating the sulfinamide or sulfonamide transition-state analogue is described. Apart from the easily accessible Gly-Xxx isosteres used as haptens to elicit catalytic antibodies, other amino acids than Gly can be prepared by α-alkylation of the sulfonamide containing peptides. This is illustrated with the synthesis of a potential HIV-protease inhibitor 27.
