148259-45-4

Basic information

• Product Name: 1-(tert-butyldimethylsiloxy)-2,2-dichloro-1-phenylpropane
• Synonyms: 1-(tert-butyldimethylsiloxy)-2,2-dichloro-1-phenylpropane
• CAS NO: 148259-45-4
• Molecular Weight: 319.346
• Mol File: 148259-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(tert-butyldimethylsiloxy)-2,2-dichloro-1-phenylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butyldimethylsiloxy)-2,2-dichloro-1-phenylpropane(148259-45-4)
• EPA Substance Registry System: 1-(tert-butyldimethylsiloxy)-2,2-dichloro-1-phenylpropane(148259-45-4)

Safety Data

• Hazardous Substances Data: 148259-45-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 138983-08-1 Dichlor<(1,1-dimethylethyl)dimethylsilyl>methan 
• 74-88-4 methyl iodide 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 93-54-9 1-Phenyl-1-propanol 
• 136116-42-2 1-phenyl-1-tert-butyldimethylsiloxypropane 

Relevant articles and documents

tert-Butyldimethylsilyldihalomethyllithium as a dihalomethylene dianion synthon. 1,3-Rearrangement and 1,4-rearrangement of silyl group from carbon to oxide

One-pot synthesis of R1CH(OSiMe2-t-Bu)CX2CH(OH)R2 (X = Cl, Br) by successive addition of two different aldehydes (R1CHO and R2CHO) has been achieved starting from tert-butyldimethylsilyldihalomethyllithium. Treatment of a THF solution of the title carbanion (X = Cl) with p-MeOC6H4CHO or n-BuCHO followed by an addition of HMPA and benzaldehyde gave the corresponding 1,3-diol monosilyl ether in 83% or 45% yield, respectively. The use of oxirane in place of aldehyde as the first electrophile followed by addition of benzaldehyde provided 1,4-diol monosilyl ether.