148290-49-7Relevant academic research and scientific papers
CDPI3-Enediyne and CDPI3-EDTA Conjugates: A New Class of DNA Cleaving Agents
Boger, Dale L.,Zhou, Jiacheng
, p. 3018 - 3024 (1993)
The synthesis and preliminary evaluation of 1a and 1b, prototypical CDPI3-enediyne and CDPI3-EDTA conjugates constituting a new class of DNA cleaving agents, are detailed.
Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation
Yu, Wensheng,Fells, James,Clausen, Dane,Liu, Jian,Klein, Daniel J.,Christine Chung,Myers, Robert W.,Wu, Jin,Wu, Guoxin,Howell, Bonnie J.,Barnard, Richard J.O.,Kozlowski, Joseph
, (2021)
A series of unique macrocyclic HDACs 1, 2, and 3 selective inhibitors were identified with good enzymatic activity and high selectivity over HDACs 6 and 8. These macrocyclic HDAC inhibitors used an ethyl ketone as the zinc-binding group. Compounds 25 and 26 stood out as leads due to their low double-digit nM EC50s in the 2C4 cell-based HIV latency reactivation assay. The PK profiles of these macrocyclic HDAC inhibitors still needed improvement.
Dual reactivity of a photochemically-generated cyclic enyne-allene
Kuzmin, Alexander V.,Popik, Vladimir V.
, p. 5707 - 5709 (2009)
A reactive ten-membered ring enyne-allene (τ25 °C = 5-6 min) is efficiently generated (Φ300 nm = 0.57) by UV irradiation of a thermally stable precursor in which a triple bond is masked as a cyclopropenone moiety.
Experimental and computational evidence for gold vinylidenes: Generation from terminal alkynes via a bifurcation pathway and facile C-H insertions
Ye, Longwu,Wang, Yanzhao,Aue, Donald H.,Zhang, Liming
supporting information; experimental part, p. 31 - 34 (2012/02/15)
Facile cycloisomerization of (2-ethynylphenyl)alkynes is proposed to be promoted synergistically by two molecules of BrettPhosAuNTf2, affording tricyclic indenes in mostly good yields. A gold vinylidene is most likely generated as one of the reaction intermediates on the basis of both mechanistic studies and theoretical calculations. Different from the well-known Rh, Ru, and W counterparts, this novel gold species is highly reactive and undergoes facile intramolecular C(sp3)-H insertions as well as O-H and N-H insertions. The formation step for the gold vinylidene is predicted theoretically to be complex with a bifurcated reaction pathway. A pyridine N-oxide acts as a weak base to facilitate the formation of an alkynylgold intermediate, and the bulky BrettPhos ligand in the gold catalyst likely plays a role in sterically steering the reaction toward formation of the gold vinylidene.
A short three-component synthesis of tricyclic compounds
Hilt, Gerhard,Korn, Tobias J.,Smolko, Konstantin I.
, p. 241 - 243 (2007/10/03)
A facile reaction sequence, consisting of a palladium-catalyzed Sonogashira coupling, a cobalt-catalyzed Diels - Alder reaction and a subsequent cyclization initiated by a bromine-lithium exchange reaction, allows a three-component synthesis of tricyclic
