547652-82-4

Upstream product

• 4724-56-5 1,4-ditosyloxybutane 
• 766-46-1 2-bromo-1-ethynylbenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 928-90-5 5-hexyl-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 148290-49-7 6-(2-bromophenyl)hex-5-yn-l-ol 

Downstream Products

• 547652-91-5 4-[2-(2-bromophenyl)-4,5-dimethyl-1,4-cyclohexadien-1-yl]butyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Switchable Synthetic Strategy toward Trisubstituted and Tetrasubstituted Exocyclic Alkenes

An efficient and facile method for the construction of tri- or tetrasubstituted exocyclic alkenes is achieved via a Cu(I)-catalytic system. This protocol exhibits mild conditions, low-cost catalyst, good functional group tolerance, and good yields. The selectivity toward tri- or tetrasubstituted alkenes can be delicately controlled by adjustment of base and solvent. A preliminary mechanism study manifested that the reaction undergoes a radical process, where B2pin2 plays an indispensable role.

A short three-component synthesis of tricyclic compounds

A facile reaction sequence, consisting of a palladium-catalyzed Sonogashira coupling, a cobalt-catalyzed Diels - Alder reaction and a subsequent cyclization initiated by a bromine-lithium exchange reaction, allows a three-component synthesis of tricyclic