148291-60-5Relevant articles and documents
Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels
Torregrosa, Robert,Yang, Xiao-Fang,Dustrude, Erik T.,Cummins, Theodore R.,Khanna, Rajesh,Kohn, Harold
supporting information, p. 3655 - 3666 (2015/07/27)
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared and then assessed using whole-cell, patch-clamp electrophysiology for their anticonvulsant activities in animal seizure models and for their sodium channel a
N-AMINOSULFONYL BENZAMIDES
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Page/Page column 75, (2013/07/19)
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulphonamide Nav 1.7 inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description. Nay 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain
Synthesis of Diaryl Ethers, Diaryl Thioethers, and Diarylamines Mediated by Potassium Fluoride-Alumina and 18-Crown-6
Schmittling, Elisabeth A.,Sawyer, J. Scott
, p. 3229 - 3230 (2007/10/02)
An efficient alternative to the copper-catalyzed synthesis (Ullmann ether synthesis) of diaryl ethers, diaryl thioethers, and diarylamines involving the potassium fluoride-alumina-mediated addition of a phenol, thiophenol, or an aniline to 2- or 4-fluorobenzonitriles catalyzed by 18-crown-6 is described.