1484-07-7Relevant articles and documents
Synthesis of alkylcarbazole aminoderivatives
Garman, Krzysztof,Olewnik, Ewa,Czerwinski, Wojciech
, p. 1 - 4 (2012)
New alkylcarbazole aminoderivatives were prepared with various alkyl chain lengths. Syntheses were evaluated and procedures simplified. Producing alkylcarbazole aminoderivatives is a two-step process, wherea-in the first step-alkycarbazol is obtained in the alkyl chain substitution reaction and the appropriate aminoderivative of alkylcarbazole is synthesized in direct amination of aromatic compounds as the second step. The products were verified with nuclear magnetic resonance analysis, and general thermal properties were determined by thermogravimetric analysis. Alkylcarbazole aminoderivatives are amphiphilic molecules, therefore expanding the list of known surfactants, compatibilizing agents, and other surface modifiers.
Alkyl Chain Introduction: In Situ Solar-Renewable Colorful Organic Mechanoluminescence Materials
Li, Wenlang,Huang, Qiuyi,Mao, Zhu,Li, Qi,Jiang, Long,Xie, Zongliang,Xu, Rui,Yang, Zhiyong,Zhao, Juan,Yu, Tao,Zhang, Yi,Aldred, Matthew P.,Chi, Zhenguo
, p. 12727 - 12732 (2018)
Mechanoluminescence (ML) materials are environmentally friendly and emit light by utilizing mechanical energy. This has been utilized in light sources, displays, bioimaging, and advanced sensors. Organic ML materials are strongly limited to application by in situ unrepeatable ML. Now, in situ solar-renewable organic ML materials can be formed by introducing a soft alkyl chain into an ML unit. For the first time, the ML from these polycrystalline thin films can be iteratively produced by simply recrystallizing the fractured crystal in situ after a contactless exposure to sunlight within a short time (≤60 s). Additionally, their ML color and lifetime can be also easily tuned by doping with organic luminescent dyes. Therefore, large-area sandwich-type organic ML devices can be fabricated, which can be repeatedly used in a colorful piezo-display, visual handwriting monitor, and sensitive optical sensor, showing a lowest pressure threshold for ML of about 5 kPa.
Design, synthesis, and biological evaluation of novel carbazole aminothiazoles as potential DNA-targeting antimicrobial agents
Addla, Dinesh,Wen, Si-Qi,Gao, Wei-Wei,Maddili, Swetha Kameswari,Zhang, Ling,Zhou, Cheng-He
, p. 1988 - 1994 (2016)
A series of novel carbazole aminothiazoles as a new type of antimicrobial agents were designed, synthesized and characterized by 1H NMR, 13C NMR, IR, MS and HRMS spectra. Some of the carbazole aminothiazoles exhibited good antimicrobial activities; particularly, heptyl-derived carbazole aminothiazole 4f could effectively inhibit the growth of MRSA with an MIC value of 4 μg mL-1, which was superior to the reference drugs Chloromycin and Norfloxacin. Moreover, cytotoxicity investigation indicated that bioactive compound 4f did not exhibit cytotoxicity to Hep-2 cells within its MIC against MRSA. Preliminary interactive investigation revealed that compound 4f could effectively intercalate into calf thymus DNA to form 4f-DNA complexes which might block DNA replication and thus exert antimicrobial activities. In addition, the binding behavior of compound 4f to DNA revealed that compound 4f could interact with DNA by hydrogen bonds and electrostatic interactions.
The aggregation induced fluorescence effect enhanced by a reasonable length of carbon chain
Zhang, Hanjun,Tao, Furong,Cui, Yuezhi,Xu, Zhen
, (2020)
Six different barbituric acid derivatives using ethyl, propyl, butyl, pentyl, hexyl and heptyl groups as hydrophobic substituents were prepared. Molecular dynamics simulation was carried out to study the effect of different carbon chain lengths on the aggregation-induced emission process. Among the compounds, the CB-5 containing a hexyl substituent exhibited the strongest Aggregation induced emission (AIE) effect, not the CB-6 with longest carbon chain. The aggregates of CB-5 was used to detect the 2, 4, 6-trinitrotoluene (TNT) in aqueous media, exhibiting a maximum quenching constant of 3.1 × 105 M? 1. The paper sensor based on CB-5 showed a superior sensitivity toward TNT both in vapor and solution. This provided a clear strategy for designing compounds that utilize the hydrophobic interaction of long-chain alkyl chains to enhance the AIE effect.
Design of multiple-target chemoprobe: “naked-eye” colorimetric recognition of Fe3+ and off–on fluorogenic detection for Hg2+ and its on-site applications
Savran, Tahir,Karuk Elmas, Sukriye Nihan,Aydin, Duygu,Arslan, Sumeyye,Arslan, Fatma Nur,Yilmaz, Ibrahim
, p. 1003 - 1023 (2022/01/11)
A novel multiple-target chemoprobe (E)-N′-((9-pentyl-9H-carbazole-3-yl)methylene)thiophene-2-carbohydrazide (CTH) was designed, successfully synthesized and employed for the detection of Hg2+ and Fe3+ ions as off–on fluorometric and colorimetric responses, respectively, in H2O/DMF (10/90, v/v, Britton–Robinson buffer, pH 7) medium. The chemoprobe CTH demonstrated high sensitivity towards Hg2+ and Fe3+, among wide range of competitive cations with low recognition limits of 5.1?nM and 5.89?μM, respectively. The complexes of the chemoprobe CTH were synthesized and characterized by 1H-NMR titration, FT-IR and MALDI-TOF MS techniques, which confirmed the binding stoichiometries and the possible sensing mechanisms, were suggested based on the hydrolysis reaction of C=N group. The practical utility of the chemoprobe CTH was revealed in quantification of the trace amounts of Hg2+ and Fe3+ in water samples. Also, a silica-coated test paper was used for the fluorescent monitoring of Hg2+, providing a novel approach for the quantitative and on-site detection in real samples. More excitingly, a smartphone application was employed for the visual detection of Fe3+ by recognizing the RGB (red/green/blue) of the chemoprobe CTH solution. Graphical abstract: [Figure not available: see fulltext.]
