1484-07-7Relevant academic research and scientific papers
Synthesis of alkylcarbazole aminoderivatives
Garman, Krzysztof,Olewnik, Ewa,Czerwinski, Wojciech
, p. 1 - 4 (2012)
New alkylcarbazole aminoderivatives were prepared with various alkyl chain lengths. Syntheses were evaluated and procedures simplified. Producing alkylcarbazole aminoderivatives is a two-step process, wherea-in the first step-alkycarbazol is obtained in the alkyl chain substitution reaction and the appropriate aminoderivative of alkylcarbazole is synthesized in direct amination of aromatic compounds as the second step. The products were verified with nuclear magnetic resonance analysis, and general thermal properties were determined by thermogravimetric analysis. Alkylcarbazole aminoderivatives are amphiphilic molecules, therefore expanding the list of known surfactants, compatibilizing agents, and other surface modifiers.
NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells
Zhang, Yu,Shen, Ting-Ting,Kirillov, Alexander M.,Liu, Wei-Sheng,Tang, Yu
, p. 7939 - 7942 (2016)
In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of 1O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.
Alkyl Chain Introduction: In Situ Solar-Renewable Colorful Organic Mechanoluminescence Materials
Li, Wenlang,Huang, Qiuyi,Mao, Zhu,Li, Qi,Jiang, Long,Xie, Zongliang,Xu, Rui,Yang, Zhiyong,Zhao, Juan,Yu, Tao,Zhang, Yi,Aldred, Matthew P.,Chi, Zhenguo
, p. 12727 - 12732 (2018)
Mechanoluminescence (ML) materials are environmentally friendly and emit light by utilizing mechanical energy. This has been utilized in light sources, displays, bioimaging, and advanced sensors. Organic ML materials are strongly limited to application by in situ unrepeatable ML. Now, in situ solar-renewable organic ML materials can be formed by introducing a soft alkyl chain into an ML unit. For the first time, the ML from these polycrystalline thin films can be iteratively produced by simply recrystallizing the fractured crystal in situ after a contactless exposure to sunlight within a short time (≤60 s). Additionally, their ML color and lifetime can be also easily tuned by doping with organic luminescent dyes. Therefore, large-area sandwich-type organic ML devices can be fabricated, which can be repeatedly used in a colorful piezo-display, visual handwriting monitor, and sensitive optical sensor, showing a lowest pressure threshold for ML of about 5 kPa.
New synthesis method of N-alkylation of carbazole under microwave irradiation in dry media
Bogdal,Pielichowski,Jaskot
, p. 1553 - 1560 (1997)
Under microwave irradiation carbazole reacts remarkably fast with a number of alkyl halides to give N-alkyl derivatives of carbazole. The reaction were carried out with high yield by simply mixing carbazole with an alkyl halide which was adsorb on potassium carbonate.
Design, synthesis, and biological evaluation of novel carbazole aminothiazoles as potential DNA-targeting antimicrobial agents
Addla, Dinesh,Wen, Si-Qi,Gao, Wei-Wei,Maddili, Swetha Kameswari,Zhang, Ling,Zhou, Cheng-He
, p. 1988 - 1994 (2016)
A series of novel carbazole aminothiazoles as a new type of antimicrobial agents were designed, synthesized and characterized by 1H NMR, 13C NMR, IR, MS and HRMS spectra. Some of the carbazole aminothiazoles exhibited good antimicrobial activities; particularly, heptyl-derived carbazole aminothiazole 4f could effectively inhibit the growth of MRSA with an MIC value of 4 μg mL-1, which was superior to the reference drugs Chloromycin and Norfloxacin. Moreover, cytotoxicity investigation indicated that bioactive compound 4f did not exhibit cytotoxicity to Hep-2 cells within its MIC against MRSA. Preliminary interactive investigation revealed that compound 4f could effectively intercalate into calf thymus DNA to form 4f-DNA complexes which might block DNA replication and thus exert antimicrobial activities. In addition, the binding behavior of compound 4f to DNA revealed that compound 4f could interact with DNA by hydrogen bonds and electrostatic interactions.
Metal-free carbazole scaffold dyes as potential nonlinear optical phores: Molecular engineering
Ghugal, Sachin G.,Katturi, Naga Krishnakanth,Ketavath, Ravi,Murali, Banavoth,Naik, Khevath Praveen Kumar,Soma, Venugopal Rao,Swetha, T.
, p. 16188 - 16197 (2020)
In the light of diverse applications of nonlinear optical (NLO) chromophores in interdisciplinary fields, there is high demand for the quest of cost-effective and facile processing of smart materials. To narrow down such potential sensitizers, a profound
The aggregation induced fluorescence effect enhanced by a reasonable length of carbon chain
Zhang, Hanjun,Tao, Furong,Cui, Yuezhi,Xu, Zhen
, (2020)
Six different barbituric acid derivatives using ethyl, propyl, butyl, pentyl, hexyl and heptyl groups as hydrophobic substituents were prepared. Molecular dynamics simulation was carried out to study the effect of different carbon chain lengths on the aggregation-induced emission process. Among the compounds, the CB-5 containing a hexyl substituent exhibited the strongest Aggregation induced emission (AIE) effect, not the CB-6 with longest carbon chain. The aggregates of CB-5 was used to detect the 2, 4, 6-trinitrotoluene (TNT) in aqueous media, exhibiting a maximum quenching constant of 3.1 × 105 M? 1. The paper sensor based on CB-5 showed a superior sensitivity toward TNT both in vapor and solution. This provided a clear strategy for designing compounds that utilize the hydrophobic interaction of long-chain alkyl chains to enhance the AIE effect.
Design, Synthesis and Photophysical Analysis of New Unsymmetrical Carbazole-Based Dyes for Dye-Sensitized Solar Cells
Ghasempour Nesheli, Faegheh,Hosseinzadeh, Behzad,Hosseinzadeh, Rahman,Tajbakhsh, Mahmood
, (2020)
The molecular design, synthesis, and characterization of di-anchoring carbazole-based dyes (Car-Cy, Car-Amin, and Car-Mal) with A-π-D-π-A-π-A structure as materials for dye-sensitized solar cells applications (DSSCs) are reported. The electron-rich carbazole moiety in the structure of synthesized dyes is connected with acceptor/ or anchoring groups (cyanoacetic acid, 4-aminobenzoic acid, and malonic acid) and π-spacers (vinylene and cynovinyl thiophene). Electronic characteristics and molecular geometry of the sensitizers were optimized using Density Functional Theory (DFT), and the influence of dye structure on their photovoltaic performances was studied. Among the synthesized dyes in this research, Car-Amin dye presents a better photovoltaic performance as a sensitizer in the constructed device, with a power conversion efficiency (PCE) of 2.27%, JSC of 5.95 mAcm?2, VOC of 0.54 V and FF of 71%. The enhanced performance of this dye could be related to the powerful electron-withdrawing characteristic of the 4-aminobenzoic acid as an acceptor group in the dye structure. Consequently, the impact of various acceptor groups on the constructed DSSC devices was examined, and the results indicated that the improvement of DSSC performance is due to the presence of 4-aminobenzoic acid as acceptor on the carbazole-based dyes.
Design of multiple-target chemoprobe: “naked-eye” colorimetric recognition of Fe3+ and off–on fluorogenic detection for Hg2+ and its on-site applications
Savran, Tahir,Karuk Elmas, Sukriye Nihan,Aydin, Duygu,Arslan, Sumeyye,Arslan, Fatma Nur,Yilmaz, Ibrahim
, p. 1003 - 1023 (2022/01/11)
A novel multiple-target chemoprobe (E)-N′-((9-pentyl-9H-carbazole-3-yl)methylene)thiophene-2-carbohydrazide (CTH) was designed, successfully synthesized and employed for the detection of Hg2+ and Fe3+ ions as off–on fluorometric and colorimetric responses, respectively, in H2O/DMF (10/90, v/v, Britton–Robinson buffer, pH 7) medium. The chemoprobe CTH demonstrated high sensitivity towards Hg2+ and Fe3+, among wide range of competitive cations with low recognition limits of 5.1?nM and 5.89?μM, respectively. The complexes of the chemoprobe CTH were synthesized and characterized by 1H-NMR titration, FT-IR and MALDI-TOF MS techniques, which confirmed the binding stoichiometries and the possible sensing mechanisms, were suggested based on the hydrolysis reaction of C=N group. The practical utility of the chemoprobe CTH was revealed in quantification of the trace amounts of Hg2+ and Fe3+ in water samples. Also, a silica-coated test paper was used for the fluorescent monitoring of Hg2+, providing a novel approach for the quantitative and on-site detection in real samples. More excitingly, a smartphone application was employed for the visual detection of Fe3+ by recognizing the RGB (red/green/blue) of the chemoprobe CTH solution. Graphical abstract: [Figure not available: see fulltext.]
Method for synthesizing carbazole derivative
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Paragraph 0013; 0072-0073, (2021/10/05)
The invention aims to provide a method for synthesizing a carbazole derivative. The method is characterized in that palladium chloride is used as a catalyst, 2, 2' - dibromobiphenyl is used as an electrophilic reagent, primary amine is taken as a nucleophile, and the carbazole derivative is directly cross-coupled under the conditions of toluene as a solvent and an air atmosphere. The method has the advantages of high yield, high selectivity, simplicity and convenience in operation and the like.
