148438-99-7

Upstream product

• 102-08-9 N,N-diphenylthiourea 
• 790-04-5 3-phenyl-2-(phenylimino)-1,3-thiazolidin-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 79-04-9 chloroacetyl chloride 
• 790-04-5 (Z)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1262233-78-2 1-[7-(4-methoxyphenyl)-3-phenyl-2-(phenylimino)-2,3-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]thiourea 
• 1262233-83-9 2-{[7-(4-methoxyphenyl)-3-phenyl-2-(phenylimino)-2,3-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]imino}-1,3-thiazolidin-4-one 
• 1262233-88-4 2-{[7-(4-methoxyphenyl)-3-phenyl-2-(phenylimino)-2,3-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]imino}-3-ethoxyphthalimido-1,3-thiazolidin-4-one 

Relevant academic research and scientific papers

One-pot synthesis of 5-arylidene-2-imino-4-thiazolidinones under microwave irradiation

A rapid and easy solvent free one-pot synthesis of 5-arylidene-2-imino-4- thiazolidinones by condensation of the thioureas with chloroacetic acid and an aldehyde under microwave-irradiation is described.

Natural eutectic salts catalyzed one-pot synthesis of 5-arylidene-2-imino- 4-thiazolidinones

The rapid, very simple and green one-pot synthesis of 5-arylidene-2-imino- 4-thiazolidinones by condensation of the thioureas with chloroacetyl chloride and an aldehyde in natural deep eutectic solvent with good to excellent yields is described.

Design, synthesis and cytotoxicity of chalcone analogs derived from 2-phenylimino-3-phenylthiazolidin-4-one

Eleven novel chalcone analogs having a 2-phenylimino-3-phenylthiazolidin-4- one core structure were designed, synthesized and investigated for cytotoxicity against murine B16 and L1210 cancer cells. Single crystal X-ray structure analyses confirmed that these chalcone analogs adopt a Z-geometry about the alkene bond. One of the compounds, 3j, which possesses a 2-chloro-5-bromo substitution in the phenyl moiety, showed moderate cytotoxicity against murine (B16) and human melanoma (MDA-MB-435) cell lines with an IC50 value of 57 and 12 μM, respectively. At 30 μM, compound 3j had virtually no effects on the microtubules in A10 cells.

Synthesis and antibacterial activity of 2-{[3-phenyl-7-substituted-2- (phenylimino)-2,3-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]imino} -3-ethoxyphthalimido-1,3-thiazolidin-4-one

In the present investigation, desired fused ring system 2-{[3-phenyl-7-substituted-2-(phenylimino)-2,3-dihydro[1,3]thiazolo[4,5-d] pyrimidin-5-yl]imino}-3-ethoxyphthalimido-1,3-thiazolidin-4-one (6a-e) have been described. N,N′-Diphenylthiourea is convert