148495-62-9Relevant academic research and scientific papers
An Electron Transfer Model for Thromboxane Biosynthesis
Takahashi, Kimio,Kishi, Morio
, p. 722 - 724 (1987)
Conversion of prostaglandin endoperoxide model compound (1) into the thromboxane B ring system (6a) and (7a) was achieved with the aid of the ferrous ion.
STUDIES ON THE DIASTEREOSELECTIVE REDUCTION OF β-HYDROXY KETONES TO 1,3-DIOLS WITH COMMON HYDRIDE REAGENTS
Bonini, Carlo,Bianco, Armandodoriano,Fabio,Romano Di,Mecozzi, Sandro,Proposito, Alessandro,Righi, Giuliana
, p. 75 - 80 (2007/10/02)
Some common reducing agents were employed in the diastereoselective reduction of several β-hydroxy ketones to their corresponding syn-1,3-diols.The use of NaBH4 with a Ti(IV) chelating species produced syn diols with a moderate to good selectivity significantly depending upon the reaction conditions chosen (solvent, temperature, nature of the titanium species).The use of LiAlH4 at low temperature, in the presence of LiI, showed a high selectivity for reduction to syn diols, thus demonstrating a possible chelating role of lithium.Some interesting preliminary results have been also obtained in the diastereoselective reduction of MEM-protected β-alkoxy ketones.
SYNTHESIS OF A PROSTAGLANDIN ENDOPEROXIDE MODEL COMPOUND AND ITS REACTION WITH ELECTRON TRANSFER REAGENTS
Takahashi, Kimio,Kishi, Morio
, p. 4737 - 4746 (2007/10/02)
5-Exo-phenyl-2,3-dioxabicycloheptane (4c) was synthesized as a model compound of prostaglandin endoperoxide (PGH) to mimic the bioconversion of PGH into thromboxane (TX).The reaction of (4c) with various electron transfer reagents was investigated.With the aid of a catalytic amount of ferrous ion, (4c) was successfully converted into the thromboxane B (TXB) skeleton.
