148517-82-2

Usage

Uses

Used in Pharmaceutical Industry:
Donepezil Impurity-OH is used as a reference compound for the development and quality control of Donepezil, a nootropic drug. Its presence in the synthesis process is crucial for ensuring the purity and efficacy of the final product, as it can impact the drug's overall performance and safety profile.
Donepezil Impurity-OH is also used as a research tool for studying the mechanism of action of Donepezil, an inhibitor of acetylcholinesterase. This enzyme inhibition is responsible for the cognitive-enhancing effects of Donepezil, making it an important compound for understanding the underlying processes involved in memory and cognitive function.
In addition to its role in the pharmaceutical industry, Donepezil Impurity-OH may have potential applications in other fields, such as chemical research or material science, where its unique chemical properties could be exploited for various purposes. However, further investigation and research would be required to determine the specific applications and benefits of this impurity in these industries.

Upstream product

• 148502-19-6 5,6-dimethoxy-1-oxoindan-3-ylammonium chloride 
• 2107-69-9 5,6-dimethoxy-1-indanone 
• 537690-41-8 3-bromo-5,6-dimethoxy-1-indanone 
• 111-34-2 -butyl vinyl ether 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 138621-67-7 N-(5,6-dimethoxy-3-oxo-indan-1-yl)-2,2,2-trifluoroacetamide 
• 34840-85-2 3-amino-3-(3,4-dimethoxyphenyl)propanoic acid 

Downstream Products

• 2097683-67-3 donepezil 
• 36517-91-6 2,3-dihydro-5,6-dimethoxy-1H-indene-1,3-dione 

Relevant academic research and scientific papers

A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions

We report a facile and highly efficient method that copper-catalyzed intramolecular annulation to synthesize 3-hydroxy-1-indanones employing simple 2-ethynylbenzaldehyde as starting materials was achieved successfully. This protocol provided a simple synthetic approach to afford 3-hydroxy-1-indanones under mild conditions in good to excellent yields.

Direct synthesis of 1-indanones via pd-catalyzed olefination and ethylene glycol-promoted aldol-type annulation cascade

A wide range of multisubstituted 1-indanones of potential pharmaceutical use were synthesized in a one-pot fashion in moderate to excellent yields via palladium catalysis in ethylene glycol. The Heck reaction first installs an enol functionality on the aromatic ring; this is followed by an ethylene glycol promoted aldol-type annulation with a neighboring carbonyl group, resulting in the formation of various 1-indanones.

Preparation method of donepezil hydrochloride related substance E

The invention relates to a preparation method of a donepezil hydrochloride related substance E. The high-yield and high-purity related substance E is obtained by taking 5,6-dimethoxy-1-indanone as a starting material through four-step reaction.

A convenient route to indane-1,3-diones and 3-hydroxyindan-1-ones

The synthesis of alkoxyindane-1,3-diones is described in four steps starting from benzaldehydes via 3-amino and 3-hydroxyindan-1-ones. Key Words: indane-1,3-diones / 3-hydroxyindan-1-ones / diazotization / oxidation