14868-37-2Relevant academic research and scientific papers
One-step synthesis of lumazine and xanthine: First co-crystal of lumazine and perchloric acid with a unique monohydrated hydronium ion (H 5O2+) mediated supramolecular assembly of the lumazine dimer
Goswami, Shyamaprosad,Maity, Annada C.,Fun, Hoong-Kun
, p. 4056 - 4064 (2008/02/13)
A perchloric acid mediated one-step synthesis of lumazine derivatives from pterins and xanthine from guanine is reported. However, 2-pivaloylamino derivatives of pterins underwent simple hydrolysis of the pivaloylamino group generating free pterin compounds, but the 2-oxo derivatives, that is, the lumazine compounds, were not obtained. A novel supramolecular assembly is constructed by the unique hydrogen bonding of H5O2 + bridging two hydrogen-bonded dimers of lumazine to form the co-crystal 21 with aqueous perchloric acid. In contrast, N2-pivaloyl- 6-bromo-5-deazapterin was simply hydrolysed to form the protonated deazapterin 22, which forms a unique six-membered cyclic hydrogen-bonded structure leading to the generation of a polymeric supramolecular assembly. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Synthesis of some new condensed pyrimidines: Thienopteridine and purine derivatives
El-Farargy,Assy,Hassanien
, p. 109 - 119 (2007/10/02)
7-Hydroxypteridine (3) and its isomeric 6-hydroxypteridine (4) were prepared by condensation of 5,6-diaminouracil (1) with ethyl thienoylpyruvate (2) in pyridine and hydrochloric acid, respectively. Compounds 3 and 4 were converted into the corresponding thienopteridines 8 and 9 upon treatment with phosphorus pentasulphide. The synthesis of pteridines 12 and 13 was achieved from nitrosouracil (10). Also, the purine 15 and condensed purine 18 were prepared.
