14869-00-2

Basic information

• Product Name: 1-Benzyloxy-2-butanol
• Synonyms: 1-Benzyloxy-2-butanol
• CAS NO: 14869-00-2
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24
• Mol File: 14869-00-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 280.7°C at 760 mmHg
• Flash Point: 114°C
• Appearance: /
• Density: 1.023g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.513
• PKA: 14.46±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyloxy-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-2-butanol(14869-00-2)
• EPA Substance Registry System: 1-Benzyloxy-2-butanol(14869-00-2)

Safety Data

• Hazardous Substances Data: 14869-00-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Faint

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Synthesis

Derived from the reaction of benzyl alcohol and 2,3-epoxybutane

Chemical reactivity

Ability to undergo oxidation, reduction, and esterification

Additional uses

Solvent and reagent in organic synthesis

Hazardous nature

Potentially hazardous chemical

Safety precautions

Should be handled with care and in accordance with proper safety guidelines

InChI:InChI=1/C11H16O2/c1-2-11(12)9-13-8-10-6-4-3-5-7-10/h3-7,11-12H,2,8-9H2,1H3

Upstream product

• 100-44-7 benzyl chloride 
• 10467-10-4 ethylmagnesium iodide 
• 60656-87-3 benzyloxyacetoaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 106-88-7 ethyloxirane 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 584-03-2 1,2-dihydroxybutane 
• 826-19-7 Benzyloxy-methyl-magnesiumchlorid 
• 123-38-6 propionaldehyde 

Downstream Products

• 56374-55-1 1-Benzyloxy-2-butanol-p-toluenesulfonate 
• 265664-91-3 1-(2-phenylmethoxy)-2-butanone 
• 214967-07-4 (S)-2-[(R)-1-(1-Benzyloxymethyl-propoxy)-ethyl]-oxirane 
• 214967-11-0 {(S)-4,4-Bis-benzenesulfonyl-1-[(R)-1-(1-benzyloxymethyl-propoxy)-ethyl]-butoxy}-tert-butyl-dimethyl-silane 
• 214967-10-9 (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentan-1-ol 
• 214967-08-5 (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-(tert-butyl-dimethyl-silanyloxy)-pentanenitrile 
• 214967-21-2 (3S,4R)-4-(1-Benzyloxymethyl-propoxy)-3-hydroxy-pentanenitrile 

Relevant articles and documents

COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES

The present invention provides novel phenylcycloalkylmethylamme derivatives, and methods of preparing phenylcycloalkylmethylamme derivatives. The present invention also provides methods of using phenylcycloalkylmethylamme derivatives and compositions of phenylcycloalkylmethylamme derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co- morbid indications and depression and depression related co-morbid indications.

SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.

Synthesis of the marine compound (2R,5Z,9Z)-2-methoxyhexacosa-5,9-dienoic acid via a lipase-catalyzed resolution and a novel O-alkylation protocol

The title compound has been synthesized by a facile route starting from 4-pentyn-1-ol. The enantioselectivity was attained by a strategy involving a lipase-catalyzed acetylation of a solid-phase immobilized long chain α-hydroxy acid. Another important feature of the synthesis was the formulation of an efficient HgO-catalyzed O-methylation of the α-hydroxy acids which proceeded without any racemization. The alkylation protocol was also highly efficient for selective mono-methylation/benzylation of symmetrical diols.