1487-51-0Relevant articles and documents
Synthesis of 1-lyso-2-palmitoyl-rac-glycero-3-phosphocholine and its regioisomers and structural elucidation by NMR spectroscopy and FAB tandem mass spectrometry
Kim, Young-Ah,Park, Myoung-Soon,Kim, Young Hwan,Han, So-Yeop
, p. 2921 - 2928 (2007/10/03)
Three regioisomers of a naturally occurring lysophosphatidylcholine were chemically synthesized from glycerol. The phosphocholine moiety of the molecule was introduced by sequentially reacting with ethylene chlorophosphite, bromine, water, and trimethyl amine. Removal of a silyl protecting group of the hydroxyl group in the glycerol backbone was achieved without any accompanying acyl migration in the final stage of the synthesis by using NBS in a dimethyl sulfoxide-water cosolvent system. Structures of all regioisomers were compared by NMR spectroscopy and FAB tandem mass spectrometry.
A GENERAL PROTOCOL FOR THE PREPARATION OF PHOSPHOLIPIDS VIA PHOSPHITE COUPLING
Martin, Stephen F.,Josey, John A.
, p. 3631 - 3634 (2007/10/02)
A method for the facile preparation of a variety of phospholipids and their derivatives has been developed that utilizes a highly efficient phosphite coupling procedure for the synthesis of a phosphite triester, which may then be readily transformed into the corresponding phosphate diester by sequential oxidation and O-deprotection.