148729-36-6 Usage
Description
1-(4-methoxybenzyl)piperidin-3-ol is a chemical compound with the molecular formula C14H21NO2. It is a piperidine derivative that features a piperidine ring with a 4-methoxybenzyl group attached to the nitrogen atom. Additionally, the compound contains a hydroxyl group (-OH) attached to the piperidine ring. Its unique structure and properties make it a promising candidate for medicinal chemistry and pharmaceutical research, particularly in the development of new therapeutic agents.
Uses
Used in Pharmaceutical Research:
1-(4-methoxybenzyl)piperidin-3-ol is used as a potential building block for the synthesis of various compounds with biological activity. Its unique structure and properties make it an interesting target for drug development, particularly in the search for new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-methoxybenzyl)piperidin-3-ol is utilized for its potential to contribute to the development of novel drugs. Its chemical structure allows for further modification and optimization to enhance its pharmacological properties, making it a valuable asset in the creation of new therapeutic options.
Used in Drug Development:
1-(4-methoxybenzyl)piperidin-3-ol is employed in drug development as a starting point for the design and synthesis of new pharmaceutical compounds. Its unique features, such as the 4-methoxybenzyl group and the hydroxyl group, provide opportunities for chemical modifications that can lead to the discovery of innovative and effective treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 148729-36-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,7,2 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 148729-36:
(8*1)+(7*4)+(6*8)+(5*7)+(4*2)+(3*9)+(2*3)+(1*6)=166
166 % 10 = 6
So 148729-36-6 is a valid CAS Registry Number.
148729-36-6Relevant articles and documents
Design and synthesis of Rho kinase inhibitors (II)
Iwakubo, Masayuki,Takami, Atsuya,Okada, Yuji,Kawata, Takehisa,Tagami, Yoshimichi,Ohashi, Hiroshi,Sato, Motoko,Sugiyama, Terumi,Fukushima, Kayoko,Iijima, Hiroshi
, p. 350 - 364 (2008/02/04)
In a previous study, we identified several structurally unrelated scaffolds of the Rho kinase inhibitor using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho kinase. 1H-Indazole is one of the candidate scaffolds on which a new series of potent Rho kinase inhibitors could be developed. In this study, the detailed structure-activity relationship of 1H-indazole analogues was studied. During this study, we found that the cell-free enzyme inhibitory potential of Rho kinase inhibitors having the 1H-indazole scaffold did not necessarily correlate with their inhibitory potential toward the chemotaxis of cultured cells. The choice of the linker substructure was shown to be an important factor for the 1H-indazole analogues to inhibit the chemotaxis of cells. Optimization of the 1H-indazole inhibitors with respect to the in vitro inhibition of monocyte chemotaxis induced by MCP-1 was carried out. The inhibitory potential was improved both in the cell-free enzyme assay and in the chemotaxis assay.