148960-33-2

Usage

Uses

Used in Organic Synthesis:
1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO is used as a building block in organic synthesis for the creation of various compounds. Its unique structure allows for versatile chemical reactions, contributing to the development of new molecules with specific properties.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO is utilized as a key intermediate in the production of pharmaceuticals. Its incorporation into drug molecules can potentially enhance their efficacy, selectivity, and pharmacokinetic profiles.
Used in Agrochemical Development:
1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO also finds application in the agrochemical sector, where it serves as a precursor for the synthesis of agrochemicals. Its use can lead to the development of more effective and targeted pesticides or other agricultural products.
Used in Specialty Chemicals Production:
1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO is employed in the production of specialty chemicals, where its unique properties can be leveraged to create high-value products for specific applications in various industries.
Used in Pharmacological Research:
1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO is studied for its potential pharmacological activities, with the aim of discovering new therapeutic agents. Its unique structure may offer novel mechanisms of action or improved properties compared to existing drugs.

Upstream product

• 7440-66-6 zinc 
• 700-84-5 5-fluoro-1-indanone 
• 148960-32-1 5-fluoro-1-indanone oxime 

Downstream Products

• 1114333-11-7 (R)-5-fluoro-2,3-dihydro-1H-inden-1-amine 

Relevant academic research and scientific papers

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

KCNT1 INHIBITORS AND METHODS OF USE

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF

Certain aspects of the invention relate to small molecule autophagy inhibitors, and their use for treatment and prevention of cancers and acute pancreatitis. Medicinal chemistry studies led to small molecular autophagy inhibitors with improved potency and selectivity.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Methods and fluorinated compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease. Also described are methods, compounds, pharmaceutical compositions and kits for detecting, diagnosing, monitoring and treating or preventing amyloid-related disease.

NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy an

Monofluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase

N-propargyl-1-amonoindan monofluorinated in the phenyl ring and their use as selective inhibitors of monoamine oxidase (MAO). There are provided several processes for the preparation of these novel compounds. There are also provided as novel compounds