14905-80-7

Usage

InChI:InChI=1/C10H14S/c1-8(2)11-10-6-4-5-9(3)7-10/h4-8H,1-3H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 87136-91-2 m-(isopropylthio)phenyl methyl selenide 
• 79128-11-3 m-(Isopropylthio)-phenyl methyl sulphide 
• 55698-06-1 m-chlorophenyl isopropyl sulfide 
• 75-16-1 methylmagnesium bromide 
• 75-30-9 2-iodo-propane 
• 108-40-7 toluene-3-thiol 
• 84321-31-3 1-methyl-3-(propane-2-sulfinyl)-benzene 
• 541-73-1 1,3-Dichlorobenzene 

Downstream Products

• 20884-64-4 3-(isopropylsulfonyl)benzoic acid 
• 84321-31-3 1-methyl-3-(propane-2-sulfinyl)-benzene 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 84413-70-7 (R)-1-(isopropylsulfinyl)-3-methylbenzene 
• 18453-16-2 N-(1-methylethyl)-3-[(1-methylethyl)sulfonyl]-benzamide 
• 51751-71-4 1-methyl-4-(propane-2-sulfonyl)benzene 
• 118-90-1 ortho-methylbenzoic acid 
• 99-94-5 p-Toluic acid 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-S Bond Cleavage

Rhodium-catalyzed transformation of alkyl aryl sulfides into arylboronic acid pinacol esters via C-S bond cleavage is reported. In combination with transition-metal-catalyzed sulfanyl group-guided regioselective C-H borylation reactions of alkylthioarenes, this method allows the synthesis of a diverse range of multisubstituted arenes.

Trimethylchlorosilane (TMCS) catalyzed efficient reduction of sulfoxides to thioethers using 3-mercaptopropionic acid under mild reaction conditions

A variety of alkyl and aryl sulfoxides were successfully deoxygenated using 3-mercaptopropionic acid as reducing agent and a catalytic amount of trimethylchlorosilane (10-20 mol%) in CH3CN at ambient temperature.

Rapid, efficient and chemoselective deoxygenation of sulfoxides to thioethers using NaBH4/I2

Sodium borohydride in the presence of iodine in anhydrous THF converts a range of structurally different sulfoxides to their thioethers in excellent yields. It has been found that chemoselective deoxygenation of sulfoxides can be achieved in the presence of other reducible functional groups such as esters, nitriles and double bonds.

N-bromosuccinimide and iodine catalyzed highly efficient deoxygenation of sulfoxides to thioethers using 3-mercaptopropionic acid under mild reaction conditions

A variety of alkyl and aryl sulfoxides have been successfdlly deoxygenated using 3-mercaptopropionic acid as a reducing agent and a catalytic amount of either NBS or I2 (5-10 mol%) in MeCN at ambient temperature. Under the described reaction condition, acid sensitive substrates such as acetals remained intact after several hours.

MONOALKYLATION AND MONOPHENYLATION OF ISOPROPYLTHIOPHENYL METHYL SELENIDES AND 2-PHENYLTHIOETHENYL METHYL SELENIDES WITH GRIGNARD REAGENTS PROMOTED BY LOW-VALENT NICKEL SPECIES. REGIO- AND STEREOSELECTIVE CLEAVAGE OF THE CARBON-SELENIUM BOND

The substitution of the methylselenium group in different (isopropylthio)phenyl and (phenylthio)ethenyl methyl selenides by alkyl and phenyl groups, through Grignard reaction mediated by phosphino-ligated nickel species, is described.In all cases this substitution occurs smoothly and at a rate which is fast enough to leave the C-S bond unaffected.In the olefinic series the use of a bidenate phosphine ligand on the nickel catalyst is required to promote the stereocontrolled cleavage of the C-Se bond in the case of the Z isomers.

SELECTIVE MONO-ARYLATION AND -ALKYLATION OF BIS(ALKYLTHIO)BENZENES; THE IMPORTANCE OF STERIC EFFECTS IN THE NICKEL-CATALYZED CROSS-COUPLING OF ARYL ALKYL SULPHIDES WITH GRIGNARD REAGENTS

Synthetically useful procedures to effect selective conversion of C-S into C-C bonds have been developed by taking advantage of the sensitivity of reactions of Grignard reagents with aryl alkyl sulphides, catalyzed by low-valent nickel species, to steric effects.It is shown that the course of these reactions is influenced by the steric requirements of both the aryl and the alkyl moieties of the sulphides.Thus, selective mono-arylation and alkylation of easily available bis(alkylthio)benzenes can be effected in medium to high yields.This allows the introduction of two different aryl or alkyl groups into the benzene nucleus by sequential substitution of the two alkylthio functions.

SELECTIVE MONO-ARYLATION AND -ALKYLATION OF CHLOROPHENYL ALKYL SULFIDES BY NICKEL CATALYSED CROSS-COUPLING WITH GRIGNARD REAGENTS

Chlorophenyl alkyl sulfides are mono-arylated and -alkylated selectively with Grignard reagents, in the presence of Ni(PPh3)2Cl2, to give aryl- and alkyl-phenyl alkyl sulfides.