1491165-16-2

Upstream product

• 87628-50-0 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1491164-96-5 C₂₁H₂₂N₄O₂ 
• 98-88-4 benzoyl chloride 
• 41979-39-9 4-piperidone hydrochloride 
• 661487-18-9 tert-butyl 3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 
• 32459-62-4 4-ethoxyphenyl isocyanate 

Relevant academic research and scientific papers

Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors

Forty 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives were synthesized from piperidin-4-one by five step synthesis and evaluated for Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibition study, in vitro activities against MTB, cytotoxicity against RAW 264.7 cell line. Among the compounds, 1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4, 3-c]pyridine-5(4H)-carboxamide (6ac) was found to be the most active compound with IC50 of 21.8 ± 0.8 μM against MTB PS, inhibited MTB with MIC of 26.7 μM and it was non-cytotoxic at 50 μM.