149169-49-3Relevant academic research and scientific papers
1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS
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Paragraph 0419, (2018/07/29)
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
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, (2018/04/17)
The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.
HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS
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Page/Page column 48, (2010/03/04)
The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are modulated by a 5-HT5 receptor activity, in particular, for treating neurodegenerative and neuropsychiatric disorders as well as signs, symptoms and dysfunctions.
Process for preparing benzo[b]naphthyridines
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, (2008/06/13)
This invention relates to a method for the preparation of benzo[b]naphthyridines having the general formula (I) STR1 comprising: 1) condensation of an amine having the formula R'--NH--CH2 --CH2 --R" with a chlorofluoroquinoline of formula (II) STR2 2) cyclization of the obtained fluoroquinoline of formula (IV) STR3 and; 3) oxidation of tetrahydro-1,2,3,4benzo[b]naphthyridine-1,8 of formula (V) STR4 is effected, and then, optionally, the ester obtained is transformed into an acid and optionally into a salt.
Derivatives of fluoro-quinoline carboxylic-3-acid and preparation therefor
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, (2008/06/13)
This invention relates to new derivatives of fluoro quinoline carboxylic-3 acid having general formula (I), STR1 wherein R is a hydrogen atom or an alkyl radical and Hal is a halogen atom, as well as salts thereof, when they exist, preparation thereof and utilization as synthesis intermediary.
