1491884-91-3Relevant academic research and scientific papers
Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues
Zhuge, Juanping,Jiang, Ziyang,Jiang, Wei,Histand, Gary,Lin, Dongen
, p. 5121 - 5126 (2021)
An efficient oxidative functionalization of purine-like substrates with (thio)ethers or methylarenes under mild conditions is described. Using I2as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives with high atom- and step-economy and exceptional functional group tolerance.
