149198-87-8

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 460754-33-0 N₄-benzyloxy-N₁-(1-(2-(S)-benzyloxymethyl-pyrrolidine-1-carbonyl)-2-(S)-methyl-propyl)-2-(R)-pentylsuccinamide 
• 460754-33-0 C₃₃H₄₇N₃O₅ 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 130603-36-0 tert-butyl (S)-2-((benzyloxy)methyl)pyrrolidine-1-carboxylate 
• 122501-62-6 tribenzyl-actinonin 
• 122501-60-4 (R)-(+)-tert-Butyl 2-(N-benzyl-N-benzyloxycarbamoylmethyl)heptanoate 
• 122501-59-1 2-benzyloxymethyl-N-(N-tert-butoxycarbonyl-L-valinyl)pyrrolidine 
• 122501-61-5 (R)-(+)-2-(N-Benzyl-N-benzyloxycarbamoylmethyl)heptanoic acid 
• 122501-58-0 N-(N-Boc-L-valyl)-L-prolinol 
• 122519-30-6 (S)-2-Amino-1-((R)-2-benzyloxymethyl-pyrrolidin-1-yl)-3-methyl-butan-1-one 
• 41120-72-3 N-Boc-L-valine o-nitrophenyl ester 
• 54124-60-6 L-Valyl-L-prolinol 
• 1321530-43-1 (1'S,2''S)-N-benzyloxy-N'-{1-[(2-hydroxymethyl)pyrrolidinylcarbonyl]-2-methylpropyl}-3-[(E)-pentylidene]succinamide 

Downstream Products

• 3507-62-8 monoamyl succinic acid 
• 3975-91-5 (R)-(+)-2-pentylsuccinic acid 

Relevant academic research and scientific papers

THE ASYMMETRIC SYNTHESIS OF (-)-ACTINONIN USING THE IRON CHIRAL AUXILIARY 5-C5H5)Fe(CO)(PPh3)>

The asymmetric synthesis of the α-pentyl succinate fragment of (-)-Actinonin is achived using the chiral ironacetyl S-(+)-5-C5H5)-Fe(CO)(PPh3)COCH3> and subsequently converted to (-)-Actinonin in an overall yield of 41percent.

Preparation method of actinonin

The invention discloses a preparation method of actinonin. The preparation method includes: taking N-Boc-L prolinol as a raw material; firstly, protecting hydroxyl, and then removing Boc protection base of amino; condensing with N-Boc-L-valine to obtain d

Synthesis of (-)-actinonin

Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent. Georg Thieme Verlag Stuttgart - New York.

Analogs and derivatives of (S,S,R)-(-)-actinonin and uses therefor

The present invention provides analog and derivative compounds of (S,S,R)-(?)-actinonin and methods of asymmetric synthesis thereof having a structure: where R1 is hydrogen, C(O)R6 or R1 in combination with N is 2-oxomorph

Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

The present invention provides methods for the asymmetric synthesis of (S,S,R)-(?)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: 1 where R1 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl

Asymmetric Synthesis of (-)-Actinonin and (-)-epi-Actinonin

The highly asymmetric induction imparted by the iron chiral auxiliary 5-C5H5)Fe(CO)(PPh3)> is exploited in the preparation of homochiral (R)- and (S)-α-pentylsuccinates.Their application in the synthesis of (-)-actinonin and (-)-epi-actinoni