149209-48-3Relevant articles and documents
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
Shao, Pengcheng P.,Ye, Feng,Weber, Ann E.,Li, Xiaohua,Lyons, Kathryn A.,Parsons, William H.,Garcia, Maria L.,Priest, Birgit T.,Smith, McHardy M.,Felix, John P.,Williams, Brande S.,Kaczorowski, Gregory J.,McGowan, Erin,Abbadie, Catherine,Martin, William J.,McMasters, Daniel R.,Gao, Ying-Duo
scheme or table, p. 5334 - 5338 (2010/04/26)
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Nav1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Nav1.7 inhibitory activity.