149209-47-2

Usage

Uses

Used in Pharmaceutical Industry:
2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane is used as an antidepressant medication for treating depression, as it helps to regulate mood by increasing serotonin levels in the brain.
Used in Treatment of Eating Disorders:
In the field of eating disorders, 2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane is used as a therapeutic agent for bulimia nervosa, helping to control binge eating and purging behaviors.
Used in Management of Obsessive-Compulsive Disorder:
2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane is utilized as a treatment for obsessive-compulsive disorder, where it aids in reducing obsessive thoughts and compulsive behaviors by modulating serotonin levels.
Used in Treatment of Panic Disorder:
In the context of panic disorder, 2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane is employed as a medication to alleviate panic symptoms and prevent panic attacks by stabilizing serotonin levels.
Used in Premenstrual Dysphoric Disorder Management:
2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane is used as a treatment for premenstrual dysphoric disorder, helping to alleviate severe emotional and physical symptoms associated with the menstrual cycle.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 444-30-4 2-(trifluoromethyl)phenol 

Downstream Products

• 149209-48-3 2-iodo-6-(trifluoromethyl)phenol 
• 46377-35-9 2,6-bis(trifluoromethyl)phenol 
• 1026369-41-4 2,6-bis(trifluoromethyl)-4-bromophenol 
• 149209-49-4 2,6-bis(trifluoromethyl)-4-bromophenol TBDMS ether 
• 1026274-93-0 1-[4-(tert-Butyl-dimethyl-silanyloxy)-3,5-bis-trifluoromethyl-phenyl]-hex-5-yn-1-one 
• 845536-43-8 C₁₂H₁₂F₃IO₂ 
• 873011-15-5 2-(tetrahydro-2H-pyran-2-yloxy)-3-(trifluoromethyl)benzaldehyde 
• 336628-67-2 2-hydroxy-3-(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

Elaborate Tuning in Ligand Makes a Big Difference in Catalytic Performance: Bulky Nickel Catalysts for (Co)polymerization of Ethylene with Promising Vinyl Polar Monomers

To reveal effect of electronic or steric modification of phosphino-phenolate nickel complex for preparing optimized catalysts, we take elaborated studies on structure-performance relationship by finely modifying substituents on ortho-phenoxy position or phosphorus moiety of this catalyst. It reveals that these newly synthesized complexes are thermally robust, and exhibits very high activity (up to 107 g molNi?1 h?1) in ethylene polymerization even at 120 °C. Associated with stoichiometric experiments, experimental results prove that nickel complexes bearing electron-withdrawing substituents on ortho-phenoxy position or electron-donating substituents on phosphorus atom show higher activity than contrastive catalysts toward ethylene polymerization and ethylene–methyl acrylate (MA) copolymerization. Among these catalysts, 3 g bearing a strong electron-withdrawing substituent on ortho-phenoxy position exhibits the highest activity, and produces copolymers with the highest molecular weight and analogous MA incorporation. Various challenging polar vinyl monomers, like polyethylene glycol monomethyl ether acrylate, can be efficiently copolymerized with ethylene.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Nav1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Nav1.7 inhibitory activity.