149210-90-2Relevant academic research and scientific papers
The phosphorus-Claisen condensation
Gavara, Laurent,Gelat, Fabien,Montchamp, Jean-Luc
supporting information, p. 817 - 820 (2013/03/13)
1,1-Bisphosphorus compounds are easily synthesized through the phosphorus-Claisen (phospha-Claisen) condensation between a phosphorus- stabilized anion and a phosphorus electrophile. The preliminary scope of this reaction is investigated in terms of employable phosphorus reagents. Valuable intermediates are conveniently prepared in a single step. Overall, the method is competitive with multistep procedures which require the preparation of PCl intermediates derived from the P(OR) reagents we instead employ directly, and it delivers complex organophosphorus compounds in moderate to good isolated yields. An example of the intramolecular version of the reaction, the phospha-Dieckmann condensation, is also reported.
PHOSPHONSAEUREESTER-PHOSPHANE ALS HEMILABILE KOMPLEXLIGANDEN
Weigt, Axel,Bischoff, Stefan
, p. 91 - 102 (2007/10/02)
New hemilabile rhodium complexes with phosphonate-phosphane ligands (RO)2P(O)(CH2)nPPh2 1a-c (n = 1 - 3) have been synthesized and characterised.Effective methods for the preparation of the ligands were developed and the characterisation was carried out w
ZUR SYNTHESE UND REAKTIVITAET METHYLENVERBRUECKTER DIPHOSPHORYLVERBINDUNGEN
Goebel, R.,Richter, F.,Weichmann, H.
, p. 67 - 80 (2007/10/02)
An improved high-yield Arbusov-type synthesis for diphosphorylmethanes with different substituents on both phosphorus atoms (4, 5, 7) by the reaction of isopropyl diphenylphosphinite or diisopropyl phenylphosphonite with diisopropyl bromomethylphosphonate (1) or isopropyl phenyl-bromomethylphosphinate (2), respectively, is described. 1 and 2 are available in yields of about 50 percent by the reaction of an excess of methylene bromide with triisopropylphosphite or diisopropyl phenylphosphonite, respectively.The metalation of the symmetrical and unsymmetrical diphosphorylmethanes 3-8 with NaH in toluene yields the corresponding carbanionic salts 3A-8A.Their structure and reactivity are investigated by means of 31P NMR spectroscopy and Horner-reactions with benzaldehyde.Regioselective monomethylation at the central carbon atom of 3-7 is performed using the phase-transfer technique.With exception of the phosphono-phosphinate derivative 14, on this way the appropriate 1,1-diphosphorylethanes 13 and 15-17 are obtained in high yield.Key words: diisopropyl bromomethylphosphonate; isopropyl phenyl-bromomethylphosphinate; diphosphorylmethanes; 31P-NMR; HORNER-reactions; 1,1-diphosphorylethanes
