149220-67-7Relevant academic research and scientific papers
Rapid and efficient synthesis of unsymmetrical phosphinic acids r′t(o)ohr″
Fougere, Cecile,Guenin, Erwann,Hardouin, Julie,Lecouvey, Marc
experimental part, p. 6048 - 6054 (2010/03/02)
A new synthesis of unsymmetrical phosphinic acids R′P(O)OHR″ has been evaluated, The first P-C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle, A onepot methodology was developed for the second P-C bond formation reaction that: involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality.
