149220-87-1Relevant articles and documents
NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE
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Page/Page column 61-62, (2008/06/13)
This invention provides novel β-lactamase inhibitors of the aryl-and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or a pro-drug or pharmaceutically acceptable salt thereof, wherein: W represents: Formula (II).
Syntheses of the acridone alkaloid citrusinine-I and its derivatives
Kato,Fujita,Fujimura,Kawashima,Nishiyama
, p. 445 - 452 (2007/10/02)
Citrusinine-I (1), a naturally occurring acridone alkaloid with potent antiviral activity, was synthesized for the first time, via a route involving Ullmann reaction, cyclization, and selective demethylation at the 1-position with boron trifluoride etherate and lithium bromide. 1,5,6-Trihydroxy-3-methoxy-9(10H)-acridone (2a) and 1,5,6-trihydroxy-3-methoxy-10-methyl-9(10H)-acridone (2b) were also synthesized.