14926-34-2

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 93-91-4 1-phenylbutan-1,3-dione 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 70769-72-1 1-phenyl-3-ethylsulfenyl-2-buten-1-one 

Downstream Products

• 106366-72-7 3a-Methyl-1,3,4a,5,7-pentaphenyl-3a,4,4a,5-tetrahydro-3H-bis<1,2,4-triazolo><4,3-a:3',4'-d><1,5>benzodiazepine 
• 162713-10-2 ethyl 3-(4-chlorophenyl)-3a-methyl-5-phenyl-3,3a,4,11-tetrahydro-3H-<1,2,4>-triazolo<4,3-a><1,5>benzodiazepine-1-carboxylate 
• 162713-11-3 3a-Methyl-3-(4-nitro-phenyl)-5-phenyl-3a,4-dihydro-3H-2,3,6,10b-tetraaza-benzo[e]azulene-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A sustainable water-tolerant catalyst with enhanced Lewis acidity: Dual activation of Cp2TiCl2 via ligand and solvent

A new strategy was developed to enhance the activity of titanocene dichloride for the synthesis of 2,4-disubstituted-3H-benzo[b]-[1,4]diazepine derivatives by using Cp2TiCl2 as a pre-catalyst. The titanocene was activated in situ in the catalytic system via the coordination with m-phthalic acid and alcohol solvent accompanied with the secession of a cyclopentadienyl ring, leading to the formation of an activated species, [CpTi(OEt)2(η1-C8H5O4)]. In particular, the novel developed half-titanocene catalyst exhibited more superior stability than representative half-titanocene complex, indicated by not only water compatibility for the employment of 30 % aqueous ethanol solution but also the recyclability that the products could be generated without apparent yield decrease after 5 runs. In general, we present a paradigm for sustainable molecular catalysis of titanocene.

Fe3O4@SiO2-CeCl3 Catalyzed Chemoselective Synthesis of Functionalized 3-Substituted-1,5-Benzodiazepines via One-pot Multicomponent and Domino Reactions

Fe3O4@SiO2-CeCl3 catalyzed chemoselective synthesis of functionalized 3-substituted-1,5-benzodiazepines via one-pot multicomponent and domino reactions has been developed. During the one-pot synthesis process, one new cycle and four new bonds (one C–C, two C–N and one C=C) were constructed by the nucleophilic addition and eliminate reaction (dehydration etc.) process, intramolecular proton transfer and cyclization process. The major advantages of the present method are good to excellent yields, shorter reaction time, simple experimental procedure, easy work up, mild reaction conditions, recyclability of the catalyst and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards.

Reactions of β-Sulfenyl α,β-Unsaturated Ketones with Guanidine, Amidines and Diamines

β-Sulfenyl α,β-unsaturated ketones 1a-c reacted with guanidine or amidines to give pyrimidine derivatives 3 in 14-76percent yields.Treatment of ketones 1 with diamines such as ethylenediamine and o-phenylenediamine afforded the seven-membered heterocycles, 2,3-dihydro-1,4-diazepine 5 and 2,3-benzo-1,4-diazepines 8a-c.