1492890-82-0Relevant academic research and scientific papers
Medium buffer effects on the condensation of l -cysteine and aryl nitriles to (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic acids
Maltsev, Oleg V.,Walter, Valerianne,Brandl, Matthias J.,Hintermann, Lukas
, p. 2763 - 2767 (2013)
The condensation of l-cysteine and aryl nitriles to (R)-2-aryl-4,5- dihydrothiazole-4-carboxylic acids in buffered media was reinvestigated. Pure products (yields of 58-95%; up to 99% ee) were obtained in a NaHCO 3/NaOH-buffered aqueous alcoholic medium. Georg Thieme Verlag Stuttgart New York.
Cu(i)-Catalyzed oxidative homo-coupling of thiazoline-4-carboxylates: Synthesis of 4,4′-bithiazoline derivatives
Fang, Xinxin,Zhang, Kaifan,Yao, Hequan,Huang, Yue
supporting information, p. 8030 - 8034 (2016/09/09)
Cu(i)-Catalyzed oxidative homo-coupling of thiazoline-4-carboxylates with good functional group tolerance has been developed. The methodology presented an efficient method to directly construct vicinal carbon-hetero quaternary centers existing in numerous functional molecules and could be applied to the synthesis of 4,4′-bithiazoles which are difficult to prepare by direct C-H activation.
