149296-21-9

Upstream product

• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 89-51-0 Homophthalic acid 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 171550-83-7 1-iodomethyl-2-vinyl-benzene 
• 178035-46-6 (S)-2-Amino-3-(2-vinyl-phenyl)-propionic acid 
• 443126-87-2 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 
• 177944-08-0 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 177944-09-1 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-formyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 443126-84-9 C₂₄H₃₂N₂O₃S₃ 
• 177944-10-4 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-{2-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-phenyl}-propionic acid 2-trimethylsilanyl-ethyl ester 
• 443126-89-4 (S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 178035-45-5 (S)-2-[(S)-4-((R)-2-Benzoylsulfanyl-3-phenyl-propionylamino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-4-methyl-pentanoic acid tert-butyl ester 
• 149296-22-0 Dimethyl <(5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl>-(2-ethenylbenzyl)propanedioate 
• 149296-20-8 2-(2-Vinyl-benzyl)-malonic acid dimethyl ester 
• 87057-53-2 Dimethyl <(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl>-(2-ethenylbenzyl)propanedioate 
• 22570-84-9 2-chloromethylstyrene 

Relevant academic research and scientific papers

The synthesis of aminobenzazepinones as anti-phenylalanine dipeptide mimics and their use in NEP inhibition

A general and stereoselective synthesis of 4-aminobenzazepinones is presented. This peptidomimetic structure was used in the preparation of MDL 100,407, a potent inhibitor of NEP.

MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

The present invention relates to certain novel mercaptoacetylamido 1,3, 4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives of the formula STR1 useful as inhibitors of enkephalinase and of ACE.