22570-84-9

Usage

Uses

Used in Polymer and Resin Production:
1-(Chloromethyl)-2-vinylbenzene is used as a monomer for the production of polystyrene and other resins. Its application is due to its ability to polymerize and form a versatile range of polymers with various properties.
Used in Synthetic Rubber Industry:
In the synthetic rubber industry, 1-(chloromethyl)-2-vinylbenzene is used as a key component in the production of rubber materials. It contributes to the development of rubber with specific characteristics, such as enhanced durability and flexibility.
Used in Fiberglass Manufacturing:
1-(Chloromethyl)-2-vinylbenzene is utilized as a precursor in the manufacturing of fiberglass. Its role is to provide the necessary chemical structure for the formation of fiberglass, which is known for its strength and lightweight properties.
Used in Pharmaceutical and Agrochemical Synthesis:
As an intermediate, 1-(chloromethyl)-2-vinylbenzene is used in the synthesis of various pharmaceuticals and agrochemicals. Its application is due to its reactivity and ability to be modified to create a wide range of compounds with different therapeutic and agricultural applications.
Safety Precautions:
It is important to handle 1-(chloromethyl)-2-vinylbenzene with caution, as exposure to high levels can be harmful to human health, causing skin and eye irritation, respiratory issues, and potentially more serious long-term effects. Proper safety measures should be taken during its production, use, and disposal to minimize health risks.

InChI:InChI=1/C9H9Cl/c1-2-8-5-3-4-6-9(8)7-10/h2-6H,1,7H2

Upstream product

• 78317-75-6 1-(2-chloroethyl)-2-chloromethylbenzene 
• 87619-44-1 o-ethylbenzylidene chloride 
• 149296-21-9 1-Chloromethyl-2-(2-mesyloxyethyl)benzene 
• 35106-82-2 2-vinylbenzylalcohol 
• 1612-65-3 2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 119-65-3 isoquinoline 
• 28272-96-0 2-vinylbenzaldehyde 
• 2039-88-5 2-bromostyrene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 22927-13-5 2-ethylbenzaldehyde 
• 22826-55-7 N,N-dimethylaminomethylstyrene 
• 764-28-3 (E)-3,3'-(diazene-1,2-diyl)bis(2-methylpropanenitrile) 
• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 89-51-0 Homophthalic acid 

Downstream Products

• 105519-14-0 N-(o-vinylbenzyl)-N-<(trimethylsilyl)methyl>amine 
• 877076-12-5 diethyl 2-(2-vinylbenzyl)malonate 
• 178035-46-6 (S)-2-Amino-3-(2-vinyl-phenyl)-propionic acid 
• 443126-87-2 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 
• 177944-08-0 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 177944-09-1 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-formyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 443126-84-9 C₂₄H₃₂N₂O₃S₃ 
• 177944-10-4 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-{2-[((S)-1-methoxycarbonyl-ethylamino)-methyl]-phenyl}-propionic acid 2-trimethylsilanyl-ethyl ester 
• 443126-89-4 (S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 178035-45-5 (S)-2-[(S)-4-((R)-2-Benzoylsulfanyl-3-phenyl-propionylamino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-4-methyl-pentanoic acid tert-butyl ester 
• 105518-97-6 N-(o-vinylbenzyl)-N-(methoxymethyl)-N-<(trimethylsilyl)methyl>amine 
• 105518-98-7 N'-(o-vinylbenzyl)-N-(o-vinylbenzyl)-N-<(trimethylsilyl)methyl>ethylenediamine 
• 91069-51-1 α-(chloromethylphenyl)ethyltriethoxysilane 
• 111783-58-5 N-methyl-1-(2-vinylphenyl)methanamine 

Relevant academic research and scientific papers

Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors

A novel and efficient approach to the synthesis of 2-vinylbenzylamines is reported. This involves obtaining 2-vinylbenzylamine ligands from tetrahydroisoquinoline by alkylation and reduction followed by the Hofmann cleavage. The resultant 2-vinylbenzyl-amines allowed us to obtain new Hoveyda–Grubbs catalysts, which were thoroughly characterised by NMR, ESIMS, and X-ray crystallography. The utility of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10?2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM).

C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF

This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.

Preparation of conformationally constrained α2 antagonists: The bicyclo[3.1.0]hexane approach

The aim of the research was to discover antagonists at α2 receptor subtypes potentially more selective than known compounds. We focused on new, conformationally restricted analogues of atipamezole. The key step in the synthetic sequences leading to target compounds relied on a rhodium-catalyzed intramolecular cyclopropanation reaction, the outcome of which varied with the nature of the diazo styrene precursor. Thus, depending on the substitution pattern of the double bond and the electronic properties of the diazo precursors, the cyclopropanes 2 or 7, naphtalenes 8, or pyrazolines 17 were formed. The byproducts 8 and 17 originated from different, nonoverlapping mechanisms. Among the racemates synthesized, three compounds (1a, 22a, and 22b) showed increased selectivity for α2A vs. α2B and α2C receptor subtypes, and consequently were prepared in enantiomerically pure form. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Mascara comprising solid particles

A composition for coating keratinous fibers, comprising, in a cosmetically acceptable medium comprising at least one volatile solvent, a nonvolatile fraction comprising: a) at least one polymer capable of adhering to the keratinous fibers, b) particles which are solid at 25° C. chosen from: i) solid particles of a crystalline or semicrystalline material, ii) solid particles of an amorphous material, iii) solid particles of at least one wax having a hardness of greater than or equal to 6.5 MPa iv) and mixtures thereof. The solid particles are present in the composition in an amount such that the volume fraction of the solid particles is less than or equal to 50% of the total volume of the said nonvolatile fraction. The composition can make it possible to obtain good curling of keratinous fibers, such as eyelashes.

Determining the scope of the lanthanide mediated, sequential hydroamination/C-C cyclization reaction: Formation of tricyclic and tetracyclic aromatic nitrogen heterocycles

The scope of the lanthanide mediated, sequential hydroamination/C-C cyclization reaction was determined for the formation of tricyclic and tetracyclic aromatic nitrogen heterocycles. An array of ring sizes was explored to determine the diastereoselectivity. The electronic characteristics of the aromatic ring was also varied to determine how it affected the cascade reaction. It was found that the benzo[a]quinolizine and the pyrido[2,1,a]isoindolizine ring systems formed with the highest diastereoselectivity (>20:1), regardless of the electronic characteristics of the aromatic ring. Additionally, a tetracyclic indole nitrogen heterocycle was formed with a 2.3:1 diastereomeric ratio. A novel procedure for substrate preparation is also presented.

MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

The present invention relates to certain novel mercaptoacetylamido 1,3, 4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives of the formula STR1 useful as inhibitors of enkephalinase and of ACE.

Polymerizable compound having mildew resistance and polymer thereof

A novel mildew resistant polymerizable compound of the formula: STR1 wherein X is --0-- or --S--; and Y is a residue of a known mildew proofing compound, preferably, a residue of a compound selected from the group consisting of phenol substituted with 1 to 5 halogen atoms, p-chloro-m-cresol, o-phenylphenol, p-chloro-m-xylenol, salicylanilide, 8-hydroxyquinoline, 2-(4'-thiazolyl)benzimidazole, 2,5-dibromo-4-methylaniline, 1,2-benzoisothiazolin-3-one and 2-pyridinethiol-1-oxide. A polymer of the compound [I] and polyurethane composition containing the polymer are also disclosed.

The synthesis of aminobenzazepinones as anti-phenylalanine dipeptide mimics and their use in NEP inhibition

A general and stereoselective synthesis of 4-aminobenzazepinones is presented. This peptidomimetic structure was used in the preparation of MDL 100,407, a potent inhibitor of NEP.

Electro-optical materials and light modulator devices containing same

Azo-type optically active compounds and polymers are provided based on compounds of the general structure wherein aryl substituents are introduced which hinder or prohibit rotation around the single bonds of the --N=-- central moiety (as well as around certain other single bonds), to provide "planarized" structures having improved optically active properties, especially electro-optically active properties. These compounds and polymers find use in optically active waveguides.

Cycloadditions of 4-pyrones. An approach to colchicine

The 4-pyrone, [5-acetoxy-4-oxo-4H-pyran-2-yl]carbonyl chloride was coupled with the malonate anion of bis(2,2,2-trichloroethyl) 2-ethenyl-3,4,5-trimethoxybenzylpropanedioate and analogs thereof. These adducts then underwent intramolecular thermal cyclizations (61-100% yield) to form the two fused seven member rings of the carbon skeleton of colchicine. The malonate moiety was deprotected and decarboxylated quantitatively to provide the desired ring system which contained a bridging ether, from C7a to C11 in the C ring, and a ketone at the 7 position. Removal of the bridging ether as H2O would yield the desired tropolone. Our attempts to remove the ether bridge were unsuccessful.