22570-84-9Relevant articles and documents
Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors
Polyanskii, Kirill B.,Alekseeva, Kseniia A.,Raspertov, Pavel V.,Kumandin, Pavel A.,Nikitina, Eugeniya V.,Gurbanov, Atash V.,Zubkov, Fedor I.
, p. 769 - 779 (2019/04/17)
A novel and efficient approach to the synthesis of 2-vinylbenzylamines is reported. This involves obtaining 2-vinylbenzylamine ligands from tetrahydroisoquinoline by alkylation and reduction followed by the Hofmann cleavage. The resultant 2-vinylbenzyl-amines allowed us to obtain new Hoveyda–Grubbs catalysts, which were thoroughly characterised by NMR, ESIMS, and X-ray crystallography. The utility of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10?2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM).
Preparation of conformationally constrained α2 antagonists: The bicyclo[3.1.0]hexane approach
Bonnaud, Bernard,Funes, Philippe,Jubault, Nathalie,Vacher, Bernard
, p. 3360 - 3369 (2007/10/03)
The aim of the research was to discover antagonists at α2 receptor subtypes potentially more selective than known compounds. We focused on new, conformationally restricted analogues of atipamezole. The key step in the synthetic sequences leading to target compounds relied on a rhodium-catalyzed intramolecular cyclopropanation reaction, the outcome of which varied with the nature of the diazo styrene precursor. Thus, depending on the substitution pattern of the double bond and the electronic properties of the diazo precursors, the cyclopropanes 2 or 7, naphtalenes 8, or pyrazolines 17 were formed. The byproducts 8 and 17 originated from different, nonoverlapping mechanisms. Among the racemates synthesized, three compounds (1a, 22a, and 22b) showed increased selectivity for α2A vs. α2B and α2C receptor subtypes, and consequently were prepared in enantiomerically pure form. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
Mascara comprising solid particles
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, (2008/06/13)
A composition for coating keratinous fibers, comprising, in a cosmetically acceptable medium comprising at least one volatile solvent, a nonvolatile fraction comprising: a) at least one polymer capable of adhering to the keratinous fibers, b) particles which are solid at 25° C. chosen from: i) solid particles of a crystalline or semicrystalline material, ii) solid particles of an amorphous material, iii) solid particles of at least one wax having a hardness of greater than or equal to 6.5 MPa iv) and mixtures thereof. The solid particles are present in the composition in an amount such that the volume fraction of the solid particles is less than or equal to 50% of the total volume of the said nonvolatile fraction. The composition can make it possible to obtain good curling of keratinous fibers, such as eyelashes.
