1493-51-2

Basic information

• Product Name: 1,3-Bis(4-fluorophenyl)-1,3-propanedione
• Synonyms: 1,3-Bis(4-fluorophenyl)-1,3-propanedione;1,3-Bis(4-fluorophenyl)propane-1,3-dione
• CAS NO: 1493-51-2
• Molecular Formula: C₁₅H₁₀F₂O₂
• Molecular Weight: 260.2355
• Mol File: 1493-51-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 402.3°Cat760mmHg
• Flash Point: 153.1°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 1.11E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 1,3-Bis(4-fluorophenyl)-1,3-propanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(4-fluorophenyl)-1,3-propanedione(1493-51-2)
• EPA Substance Registry System: 1,3-Bis(4-fluorophenyl)-1,3-propanedione(1493-51-2)

Safety Data

• Hazardous Substances Data: 1493-51-2(Hazardous Substances Data)

Usage

General Description

1,3-Bis(4-fluorophenyl)-1,3-propanedione, also known as FLU, is a chemical compound with the molecular formula C15H10F2O2. It is a yellow crystalline solid with a melting point of 102-104°C. FLU is commonly used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its versatile chemical structure allows it to participate in a variety of reactions, making it a valuable tool for organic chemists. Additionally, FLU has potential applications in the fields of materials science and biochemistry due to its unique properties. However, it is important to handle FLU with care as it is a hazardous substance that can cause irritation to the eyes, skin, and respiratory system.

InChI:InChI=1/C15H10F2O2/c16-12-5-1-10(2-6-12)14(18)9-15(19)11-3-7-13(17)8-4-11/h1-8H,9H2

Upstream product

• 403-33-8 methyl 4-flurobenzoate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1420041-65-1 1,3-bis(4-fluorophenyl)propyl-2-yn-1-one 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 
• 155886-73-0 2,2-Dimethyl-1,3-bis(4'-fluorophenyl)-1,3-propanedione 
• 1493-47-6 3,5-bis-(4-fluoro-phenyl)-1H-pyrazole 

Relevant articles and documents

Br?nsted acid-catalyzed enantioselective addition of 1,3-diones to in situ generated N-acyl ketimines

A Br?nsted acid-catalyzed asymmetric Mannich-type addition of 1,3-diones to cyclic N-acyl ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl-substituted isoindolinones bearing a quaternary carbon stereocenter were synthesized with excellent yields (up to 98%) and moderate to high enantioselectivities (up to 95% ee), and most of them possess a fluorine atom at the reactive center. Furthermore, the synthetic utility of the protocol has been demonstrated by the debenzoylation of the product.

I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives

An I2-promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3+2] cyclization reaction involves C?S and C?N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields. (Figure presented.).

Method of preparing 1,3-diketone compound by acetyenic ketone

The invention relates to a preparation method of preparing a 1,3-diketone compound by acetyenic ketone. The preparation method comprises the following steps: S1, putting alpha-alkynyl ketone compound,water, gold salt and silver salt in a reaction solvent to obtain a precursor mixture, wherein the molar ratio of the alpha-alkynyl ketone compound, water, gold salt and silver salt is 1: (1-50): (0.001-0.10): (0.002-0.15); and S2, putting the precursor mixture obtained in the S1 to react at a reaction temperature of 0-50 DEG C to obtain the 1,3-diketone compound, wherein the reaction time is 5 min to 48 h. The method is simple in reaction condition, free of acid or alkaline additives and high in yield, and can be applied to modern production on a large scale.