149353-71-9

Basic information

• Product Name: 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID
• Synonyms: 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID;2-Boc-1,3-dihydro-isoindole-5-carboxylic acid;2-[(tert-Butoxy)carbonyl]-2,3-dihydro-1H-isoindole-5-carboxylicacid
• CAS NO: 149353-71-9
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.29
• Mol File: 149353-71-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 412.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• PKA: 4.39±0.20(Predicted)
• CAS DataBase Reference: 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID(149353-71-9)
• EPA Substance Registry System: 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID(149353-71-9)

Safety Data

• Hazardous Substances Data: 149353-71-9(Hazardous Substances Data)

Usage

General Description

2-(tert-butoxycarbonyl)isoindoline-5-carboxylic acid is a chemical compound with the molecular formula C15H19NO5. It is a derivative of isoindoline-5-carboxylic acid, containing a tert-butoxycarbonyl group at the 2-position. 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID is commonly used in organic synthesis as a protecting group for amines and other reactive functional groups, due to its stability and ease of removal under mild conditions. It is also used in the production of pharmaceuticals and agrochemicals, as well as in research and development of new chemical compounds.

Upstream product

• 691-64-5 di-tert-butyl oxalate 
• 127168-94-9 methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 1203600-37-6 2-tert-butyl 5-ethyl 1,3-dihydro-2H-isoindole-2,5-dicarboxylate 
• 201940-08-1 5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 368441-44-5 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate 

Downstream Products

• 1035216-60-4 tert-butyl 5-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)isoindoline-2-carboxylate 
• 685565-60-0 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-cyanoisoindoline 
• 263888-56-8 tert-butyl 5-cyanoisoindoline-2-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUND

The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES

The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.