149396-34-9

Basic information

• Product Name: METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE
• Synonyms: METHYL 3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXYLATE;METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE;2H-1,4-Benzoxazine-8-carboxylic acid, 3,4-dihydro-3-oxo-, methyl ester
• CAS NO: 149396-34-9
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.184
• Mol File: 149396-34-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE(149396-34-9)
• EPA Substance Registry System: METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE(149396-34-9)

Safety Data

• Hazardous Substances Data: 149396-34-9(Hazardous Substances Data)

Usage

General Description

METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE is a chemical compound with a complex molecular structure. It belongs to the oxazine class of chemicals and is characterized by a 3-oxo-3,4-dihydro substitution. The presence of a carboxylate group suggests potential use in pharmaceutical or organic synthesis applications. METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE may have potential uses in medicinal chemistry or as a precursor in the synthesis of other complex organic molecules. Further research and analysis are required to fully understand the potential uses and characteristics of METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE.

Upstream product

• 85-38-1 3-nitrosalicylic acid 
• 22621-41-6 2-hydroxy-3-nitro-benzoic acid methyl ester 
• 35748-34-6 methyl 3-aminosalicylate 
• 79-04-9 chloroacetyl chloride 
• 64241-01-6 methyl 2-amino-6-hydroxybenzoate 
• 873862-31-8 3-(2-chloro-acetylamino)-2-hydroxy-benzoic acid methyl ester 

Downstream Products

• 1017273-27-6 4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester 
• 208772-72-9 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid 

Relevant articles and documents

Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors

Poly(ADP-ribose) polymerase 1 (PARP1), a widely explored anticancer drug target, plays an important role in single-strand DNA break repair processes. High-throughput virtual screening (HTVS) of a Maybridge small molecule library using the PARP1-benzimidazole-4-carboxamide co-crystal structure and pharmacophore model led to the identification of eleven compounds. These compounds were evaluated using recombinant PARP1 enzyme assay that resulted in the acquisition of three PARP1 inhibitors: 3 (IC50 = 12 μM), 4 (IC50 = 5.8 μM), and 10 (IC50 = 0.88 μM). Compound 4 (2,3-dihydro-1,4-benzodioxine-5-carboxamide) was selected as a lead and was subjected to further chemical modifications, involving analogue synthesis and scaffold hopping. These efforts led to the identification of (Z)-2-(4-hydroxybenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (49, IC50 = 0.082 μM) as the most potent inhibitor of PARP1 from the series.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.