35748-34-6

Basic information

• Product Name: 3-Amino-2-hydroxybenzoic acid methyl ester
• Synonyms: 3-Amino-2-hydroxybenzoic acid methyl ester;Methyl 3-amino-2-hydroxybenzoate;2-Hydroxy-3-(methoxycarbonyl)aniline, 2-Amino-6-(methoxycarbonyl)phenol;Methyl 3-aMinosalicylate, 95%;Benzoic acid,3-aMino-2-hydroxy-, Methyl ester
• CAS NO: 35748-34-6
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 35748-34-6.mol
• Article Data: 34

Chemical Properties

• Melting Point: 120℃ (dichloromethane )
• Boiling Point: 274.919 °C at 760 mmHg
• Flash Point: 120.067 °C
• Appearance: /
• Density: 1.306 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DMSO, Methanol
• PKA: 9.55±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-2-hydroxybenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-hydroxybenzoic acid methyl ester(35748-34-6)
• EPA Substance Registry System: 3-Amino-2-hydroxybenzoic acid methyl ester(35748-34-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 35748-34-6(Hazardous Substances Data)

Usage

Uses

3-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.

InChI:InChI=1/C8H9NO3/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4,10H,9H2,1H3

Upstream product

• 67-56-1 methanol 
• 570-23-0 3-aminosalicylic acid 
• 22621-41-6 2-hydroxy-3-nitro-benzoic acid methyl ester 
• 91983-31-2 methyl 5-bromo-2-hydroxy-3-nitrobenzoate 
• 85-38-1 3-nitrosalicylic acid 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 

Downstream Products

• 149396-34-9 methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate 
• 1175529-88-0 benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate 
• 1175529-91-5 benzyl 2-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)-2-methylpyrrolidine-1-carboxylate 
• 1175528-84-3 methyl 3-(2-fluoro-4-(pyridin-2-yl)benzamido)-2-hydroxybenzoate 
• 1175528-96-7 benzyl 2-(3-fluoro-4-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamyl)phenyl)pyrrolidine-1-carboxylate 
• 1646868-64-5 benzo[d]oxazole-7-yl methanol 
• 570-23-0 3-aminosalicylic acid 

Relevant articles and documents

Substituted pyrazole compound, preparation method, pharmaceutical composition and applications thereof

The invention discloses a substituted pyrazole compound represented by a formula I, and a preparation method, a pharmaceutical composition and applications thereof, wherein the compound has characteristics of good stability, excellent solubility, low cytotoxicity and remarkable neuroprotective effect, can effectively prevent and treat nerve cell injury, and is an ideal medicinal compound for preventing or treating cerebral stroke, cerebral embolism, cerebral stroke sequelae, cerebral stroke dyskinesia, mitochondrial encephalomyopathy and amyotrophic lateral sclerosis of spinal cord.

Benzo wicked zuozuo apperception compound and its preparation and use

The invention provides a benzoxazole compound. The structure of the benzoxazole compound is shown in the formula (I), wherein R1, R2, R3 and R4 are hydrogen, C1-C5 alkyl, benzyl, aryl or hetero aryl. The preparation method of the benzoxazole compound is carried out according to the following reaction route. Compared with the prior art, the benzoxazole compound has the benefits that the Sortase A protease of bacteroid is used as a target spot, a similar structure of a Sortase A substrate is constructed through the action mechanism of the known Sortase A and the cell wall of a host cell, and new compounds with benzoxazole and mother nucleus are synthesized; the new compounds carry out the test screening of Sortase A activity inhibition so as to try to find candidate compounds for effectively inhibiting staphylococcus aureus infection.

Synthesis, biological evaluation and molecular docking of 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives as potential Staphylococcus aureus Sortase A inhibitors

A series of novel 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives were designed, synthesized and evaluated for their in vitro inhibitory activities against Staphylococcus aureus Sortase A with known Sortase A inhibitor pHMB as positive compound (IC50?=?130?μM). Most compounds exhibited excellent inhibitory activity (IC50?=?19.8–184.2?μM). Structure–activity relationship studies demonstrated that substitution at 7-position and 2-position of benzoxazole had great influence on the activities. Specifically, the substituent at 7-position is indispensable for inhibitory activity. The molecular docking studies revealed the i-butyl amide group went towards the β6/β7 loop-β8 substructure of the protein and the benzoxazole core lied in a hydrophobic pocket composed of Ala118, Val166, Val168, Val169 and Ile182, shaping the whole molecule into a L-shape mode to be recognized by Sortase A.