1494-26-4

Basic information

• Product Name: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE
• Synonyms: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE;N-(3-TRIFLUOROMETHYLPHENYL)-P-ANISIDINE;trifluoromethylmethoxydiphenylamine;3-TRIFLUOROMETHYL-4-METHOXYDIPHENYLAMINE 98+%;4-Methoxyphenyl 3-(trifluoromethyl)phenylamine;N-(m-Trifluoromethylphenyl)-p-anisidine;N-(4-Methoxyphenyl)-3-(trifluoromethyl)aniline
• CAS NO: 1494-26-4
• Molecular Formula: C₁₄H₁₂F₃NO
• Molecular Weight: 267.25
• Mol File: 1494-26-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 58 °C
• Boiling Point: 330.7°Cat760mmHg
• Flash Point: 153.8°C
• Appearance: /
• Density: 1.254g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 0.33±0.50(Predicted)
• CAS DataBase Reference: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE(1494-26-4)
• EPA Substance Registry System: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE(1494-26-4)

Safety Data

• Hazardous Substances Data: 1494-26-4(Hazardous Substances Data)

Usage

General Description

3-Trifluoromethyl-4'-methoxydiphenylamine is a chemical compound composed of aromatic rings and functional groups. It is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals. 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE has a trifluoromethyl group and a methoxy group attached to diphenylamine, making it a versatile building block for synthesizing other organic compounds. It is also used in the production of dyes, pigments, and polymers. 3-Trifluoromethyl-4'-methoxydiphenylamine is a stable and non-reactive compound, making it suitable for use in various industrial processes and applications.

Upstream product

• 98-46-4 3-trifluoromethylnitrobenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 100-17-4 para-methoxynitrobenzene 
• 104-94-9 4-methoxy-aniline 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 623-12-1 4-chloromethoxybenzene 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 1448121-58-1 N-(4-methoxyphenyl)-2,6-dimethyl-N-(3-(trifluoromethyl)phenyl)aniline 
• 1448121-57-0 N,N-bis(4-methoxyphenyl)-3-(trifluoromethyl)aniline 
• 1448121-56-9 N-(4-methoxyphenyl)-N-p-tolyl-3-(trifluoromethyl)aniline 
• 142621-05-4 N,N'-bis (3-trifluoromethylphenyl)-N,N'-bis (4-methoxyphenyl)-(1,1'-biphenyl)-4,4'-diamine 

Relevant articles and documents

Erratum: Carbon-heteroatom coupling using Pd-PEPPSI complexes (Organic Process Research and Development (2014) 18 (180-190) DOI: 10.1021/op400278d)

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Light-Promoted C–N Coupling of Aryl Halides with Nitroarenes

A photochemical C–N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a NiII complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald–Hartwig C–N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a NiI/NiIII cycle, to a nitrosoarene intermediate.

Benzyloxycalix[8]arene supported Pd-NHC cinnamyl complexes for Buchwald-Hartwig C-N cross-couplings

The scalable synthesis of Pd-NHC cinnamyl complexes supported on benzyloxycalix[8]arene is reported. These catalysts are very active for Buchwald-Hartwig cross-coupling reactions, allowing the coupling of aryl chlorides and bromides with a wide variety of alkyl and aryl amines using low catalytic loadings. The supported complexes also successfully afforded attractive unsymmetrical triarylamines, and in one case, promoted the synthesis of an unprecedented Pd-catalyzed C-H activation product. Thanks to the calixarenic support, the target products could be isolated with low levels of residual palladium, and in some cases, even below the restrictive toxic metal standards applied by the pharmaceutical industry. Through an easy to implement procedure, these perfectly characterised catalysts thus combine the best of homogeneous and heterogeneous catalysis: high efficiency (similar to or even better than the corresponding homogeneous complexes) and low Pd leaching levels expected from heterogeneous catalysts.