149467-73-2Relevant academic research and scientific papers
Palladium-catalyzed domino cyclization (5-exo/3-exo), ring- expansion by palladium rearrangement, and aromatization: An expedient synthesis of 4-arylnicotinates from Morita-Baylis-Hillman adducts
Kim, Ko Hoon,Kim, Se Hee,Lee, Hyun Ju,Kim, Jae Nyoung
, p. 1977 - 1983 (2013/08/23)
Various 4-arylnicotinate derivatives were synthesized via a palladium-catalyzed cascade reaction of N-(2-bromoallyl)-N-cinnamyltosylamides in a one-pot procedure in good yields. The reaction involves a domino 5-exo/3-exo carbopalladation, ring-expansion b
SYNTHESES OF 2-AZAFLUORENONES FROM 3-SUBSTITUTED 4-ARYLPYRIDINES
Shiao, Min-Jen,Liu, Kang-Hsiuan,Lin, Pen-Yuan
, p. 507 - 518 (2007/10/02)
3-substituted 4-arylpyridines (5a-i) were synthesized in good yields by reaction of mixed copper, zinc aryl organometallics (2a-e) with 1-ethoxycarbonylpyridinium chlorides (1a-d) followed by o-chloranil oxidation under reflux in toluene.The arylpyridines (5a-i) are obtained predominantly.Having compounds (5a-i) in hand, a convenient method was developed for the synthesis of 2-azafluorenones (7a-f) by using cyclization of 4-arylpyridines (5a-i) with phosphoric acid.
