149490-03-9

Basic information

• Product Name: 8-chloropyrido[2,3-b][1,5]benzoxazepin-5(6H)-one
• Synonyms: 8-chloropyrido[2,3-b][1,5]benzoxazepin-5(6H)-one
• CAS NO: 149490-03-9
• Molecular Formula: C12H7ClN2O2
• Molecular Weight: 246.64918
• Mol File: 149490-03-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-chloropyrido[2,3-b][1,5]benzoxazepin-5(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloropyrido[2,3-b][1,5]benzoxazepin-5(6H)-one(149490-03-9)
• EPA Substance Registry System: 8-chloropyrido[2,3-b][1,5]benzoxazepin-5(6H)-one(149490-03-9)

Safety Data

• Hazardous Substances Data: 149490-03-9(Hazardous Substances Data)

Upstream product

• 95-85-2 2-hydroxy-5-chloro-aniline 
• 52200-48-3 3-bromo-2-chloropyridine 
• 15226-74-1 dicobalt octacarbonyl 
• 36178-05-9 3-bromo-2-fluoropyridine 
• 201230-82-2 carbon monoxide 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 153144-00-4 N-(2-hydroxy-5-chlorophenyl)-2-chloro-3-pyridinecarboxamide 

Downstream Products

• 1358939-81-7 5-((1-benzylpiperidin-4-yl)amino)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine 
• 1204575-21-2 5-(4-phenylethylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine 
• 1358939-67-9 5-(4-benzylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine 
• 1358939-66-8 5-(4-phenylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine 

Relevant articles and documents

One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source

A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones from commercially available aryl/heteroaryl halides and amino phenols using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramolecular cyclization to give dibenzoxazepinones/pyridobenzoxazepinones.

Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: Synthesis and neurochemical study

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N- methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)- pyrido[2,3-b][1,4]benzoxazepine (9) and 8-chloro-6-(4-methylpiperazin-1- yl)pyrido[2,3-b][1,4]-benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity.