1495-56-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-Hexanedione, 1,1,1-trifluoro-6-phenylis used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,4-Hexanedione, 1,1,1-trifluoro-6-phenylis employed as a key intermediate in the production of agrochemicals. Its incorporation into these compounds aids in the development of effective pesticides and other agricultural products designed to protect crops and enhance agricultural yields.
Used as a Reagent in Chemical Synthesis:
2,4-Hexanedione, 1,1,1-trifluoro-6-phenylserves as a reagent in various chemical synthesis processes. Its properties allow it to participate in a range of reactions, facilitating the creation of diverse chemical products across different industries.
Safety Considerations:

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 100-39-0 benzyl bromide 
• 53856-98-7 4-phenyl-2-butanone dimethyl acetal 
• 1544273-21-3 1,1,1-trifluoro-4-methoxy-6-phenylhex-3-en-2-one 
• 383-63-1 ethyl trifluoroacetate, 
• 2550-26-7 4-Phenyl-2-butanone 

Downstream Products

• 1251536-52-3 C₁₈H₂₇F₃O₂Si₂ 

Relevant academic research and scientific papers

Transaminases as suitable catalysts for the synthesis of enantiopure β,β-difluoroamines

Transaminases have shown the ability to catalyze the amination of a series of aliphatic and (hetero)aromatic α,α-difluorinated ketones with high stereoselectivity, thus providing the corresponding β,β-difluoroamines in high isolated yields (55–82%) and ex

An acetal acylation methodology for producing diversity of trihalomethyl-1,3-dielectrophiles and 1,2-azole derivatives

A series of functionalized 1,1,1-trihalo-4-methoxy-3-alken-2-ones [CX3C(O)CR1=CROMe, where X = F or Cl; R = n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-tridecyl, (CH2)2CH=C(Me)2, (CH2)2Ph, (CH2)2-(4-HOC6H4), (CH2)2-(4-MeOC6H4), (CH2)2CO2Me, (CH2)3CO2Me, CH(SMe)CH3, CH2(2-MeOC6H4), and R1 = H, and R = H and R1 = n-decyl] were synthesized from respective alkyl methyl ketones or aldehyde via acetal acylation using trifluoroacetic anhydride and trichloroacetyl chloride. 1,1,1-Trihalo-4-methoxy-3-alken-2-ones with acid-compatible substituents were easily hydrolyzed to respective trihalomethyl-1,3-diketones. The 1,1,1-trihalo-4-methoxy-3-alken-2-ones and/or respective trihalomethyl-1,3-diketones were reacted regiospecifically with hydroxylamine hydrochloride, leading to isoxazole derivatives, and with hydrazines, leading to respective 1H-pyrazole derivatives. The structures of all compounds were assigned based on nuclear magnetic resonance (NMR) and mass spectrometric data. This method represents an efficient pathway for the regioselective trihaloacetylation of asymmetrically substituted alkyl methyl ketones and highly self-condensing aldehydes. Moreover, this approach allows the introduction of biologically recognizable moieties, such as those from levulinic acid, sulcatone (prenyl), benzylacetone, anisylacetone, and raspberry ketone, as synthetic molecular targets.

Synthesis and reactions of the first fluoroalkylated 1,3- bis(trimethylsilyloxy)-1,3-butadienes

The first fluoroalkylated 1,3-bis(silyloxy)-1,3-butadienes have been prepared. Their reaction with oxalyl chloride provides a convenient approach to fluoroalkylated γ-alkylidenebutenolides.

Modulators of LXR

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.