149505-87-3

Basic information

• Product Name: 3-(3-Nitrophenyl)benzoic acid
• Synonyms: 3-(3-Nitrophenyl)benzoic acid;3'-Nitrobiphenyl-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylicacid, 3'-nitro-
• CAS NO: 149505-87-3
• Molecular Formula: C13H9NO4
• Molecular Weight: 243.21
• Mol File: 149505-87-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-Nitrophenyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-Nitrophenyl)benzoic acid(149505-87-3)
• EPA Substance Registry System: 3-(3-Nitrophenyl)benzoic acid(149505-87-3)

Safety Data

• Hazardous Substances Data: 149505-87-3(Hazardous Substances Data)

Upstream product

• 2453-41-0 3-nitroperbenzoic acid 
• 65-85-0 benzoic acid 
• 952-03-4 3-methyl-3'-nitro-1,1'-biphenyl 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 904-58-5 bis-(3-nitro-benzoyl)-peroxide 
• 585-79-5 m-nitrobromobenzene 
• 149506-24-1 3'-nitro-[1,1'-biphenyl]-3-carboxylic acid methyl ester 
• 121-90-4 m-nitrobenzoic acid chloride 

Relevant articles and documents

Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents

Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new alternatives to traditional antibiotics in attempts to overcome the rise of antibiotic resistance in many microbes. AMPs are part of the natural defenses of most living organisms and they also have a unique mechanism of action against bacteria. Herein, a new series of short amphiphilic cationic peptidomimetics were synthesized by incorporating the 3′-amino-[1,1′-biphenyl]-3-carboxylic acid backbone to mimic the essential properties of natural AMPs. By altering hydrophobicity and charge, we identified the most potent analogue 25g that was active against both Gram-positive Staphylococcus aureus (MIC = 15.6 μM) and Gram-negative Escherichia coli (MIC = 7.8 μM) bacteria. Cytoplasmic permeability assay results revealed that 25g acts primarily by depolarization of lipids in cytoplasmic membranes. The active compounds were also investigated for their cytotoxicity to human cells, lysis of lipid bilayers using tethered bilayer lipid membranes (tBLMs) and their activity against established biofilms of S. aureus and E. coli.

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.