149539-81-1

Basic information

• Product Name: 6-AMino-2-Methoxypyridine-3-carboxylic acid Methyl ester
• Synonyms: 6-AMino-2-Methoxypyridine-3-carboxylic acid Methyl ester;Methyl 6-aMino-2-Methoxynicotinate
• CAS NO: 149539-81-1
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.1766
• Mol File: 149539-81-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 331.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.240±0.06 g/cm3(Predicted)
• PKA: 2.60±0.37(Predicted)
• CAS DataBase Reference: 6-AMino-2-Methoxypyridine-3-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMino-2-Methoxypyridine-3-carboxylic acid Methyl ester(149539-81-1)
• EPA Substance Registry System: 6-AMino-2-Methoxypyridine-3-carboxylic acid Methyl ester(149539-81-1)

Safety Data

• Hazardous Substances Data: 149539-81-1(Hazardous Substances Data)

Upstream product

• 1026162-63-9 6-amino-2-methoxy-3-trimethoxymethylpyridine 
• 680208-55-3 2-methoxy-6-(4-methoxy-benzylamino)-nicotinic acid methyl ester 
• 19798-81-3 2-Amino-6-bromopyridine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 1211533-83-3 5- bromo-6-methoxypyridin-2-amine 
• 89284-11-7 5,6-dibromopyridin-2-ylamine 
• 65515-32-4 methyl 6-chloro-2-methoxypyridine-3-carboxylate 
• 65515-28-8 methyl 2,6-dichloronicotinate 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 848591-03-7 C₁₅H₁₆N₂O₃ 
• 405160-55-6 6-dibenzylamino-2-chloro-3-trifluoromethylpyridine 
• 405160-56-7 6-dibenzylamino-2-methoxy-3-trifluoromethylpyridine 
• 405160-57-8 6-amino-2-methoxy-3-trifluoromethylpyridine 

Downstream Products

• 680208-62-2 6-methoxy-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 680208-61-1 6-methoxy-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester 

Relevant articles and documents

PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

2-ALKOXY-6-AMINO-5-HALOGENO-N-(1-SUBSTITUTED-4-PIPERIDINYL)PYRIDINE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a compound exhibiting high affinity for serotonin 4 receptor and useful as a digestive tract motion promoting agent or digestive tract function ameliorating agent. SOLUTION: The compound is represented by the formula(I), or an acid addition salt thereof and an intermediate thereof are provided. In formula(I), R1 is a halogen atom; R2 is H or a lower alkyl; R3 is H, a lower alkyl or the like; R4 is a lower alkyl; A is a group represented by the formula: Z-N(Q1)(Q2) or CO-R5, wherein Z is CO, CS or the like; Q1 and Q2 are each H, a lower alkyl or the like, or joined together with the nitrogen atom to which Q1 and Q2 are bound to form a pyrrolidine ring, piperidine ring or the like; and R5 is H, a lower alkyl, lower alkoxy, lower alkoxycarbonyl or the like.

Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6- yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors

A series of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamide derivatives were prepared and evaluated for their binding to 5-HT3 and dopamine D2 receptors. Among them, the 5-bromo-2-methoxy-6- methylaminonicotinamide 16 and its (R)-isomer were found to have potent affinities for both receptors. The affinities of (R)-16 for 5-HT3 and dopamine D2 receptors are approximately 3-fold higher than those of the corresponding benzamide (R)-1 (IC50: 1.1 and 12 nM vs. 2.9 and 35 nM, respectively).