405160-57-8 Usage
General Description
6-Methoxy-5-(trifluoromethyl)pyridin-2-amine is a chemical compound with the molecular formula C7H8F3NO. It is a pyridine derivative with a methoxy group and a trifluoromethyl substituent on the 5th and 2nd carbon atoms, respectively. 6-Methoxy-5-(trifluoroMethyl)pyridin-2-aMine is used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active molecules and crop protection agents. It is also used in research and development for medicinal chemistry and drug discovery. 6-Methoxy-5-(trifluoromethyl)pyridin-2-amine is an important intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 405160-57-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,1,6 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 405160-57:
(8*4)+(7*0)+(6*5)+(5*1)+(4*6)+(3*0)+(2*5)+(1*7)=108
108 % 10 = 8
So 405160-57-8 is a valid CAS Registry Number.
405160-57-8Relevant articles and documents
A practical preparation of methyl 2-methoxy-6-methylaminopyridine-3-carboxylate from 2,6-dichloro-3-trifluoromethylpyridine
Horikawa,Hirokawa,Kato
, p. 1621 - 1627 (2007/10/03)
An effective and practical synthetic route to methyl 2-methoxy-6-methylaminopyridine-3-carboxylate (7), the key intermediate of 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid (1), from 2,6-dichloro-3-trifluoromethylpyridine (12) was undertaken. Process improvements were highlighted by regioselectivity of 12 with a nitrogen nucleophile and conversion of the 3- trifluoromethyl group into the methoxycarbonyl group. The reaction of 12 with N-benzylmethylamine provided the 6-(N-benzyl-N-methyl)aminopyridine 26a and the regioisomer 26b in >98: 2 ratio in a quantitative yield. Treatment of 2-methoxy-6-methylamino-3-trifluoropyridine (14a) with a large excess of sodium methoxide followed by acid hydrolysis gave the pyridine-3-carboxylic ester 7 in an excellent yield. The potential application of this reaction is also described.
