14958-00-0Relevant articles and documents
PYRAZOLE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
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Page/Page column 198; 199, (2018/02/03)
The present invention relates to pyrazole derivatives of formula (I) having pharmacological activity towards the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
Intramolecular electron transfer initiated cation and radical formation through carbon-carbon bond activation
Wangyang, Tu,Floreancig, Paul E.
, p. 2389 - 2392 (2008/02/05)
Radical cations can be formed in a spatially and temporally controlled manner by appending a sacrificial photooxidant to an easily oxidized substrate, leading to intramolecular electron transfer upon irradiation. The anthraquinone carboxyl group is an effective photooxidant that can promote single electron oxidation from an appended arene. The resulting intermediates undergo a cleavage reaction through carbon-carbon bond activation to provide either cations or radicals that react to form a range of products.
Microwave-assisted Ketone-Ketone rearrangement: An improved synthesis of 3-(4-Alkoxyphenyl)-3-methylbutan-2-ones
Gopalakrishnan, Geetha,Kasinath, Viswanathan,Singh, N. D. Pradeep
, p. 781 - 782 (2007/10/03)
(formula presented) A novel procedure for the preparation of 3-(4-alkoxyphenyl)-3-methylbutan-2-one in excellent yield is described via polymer-supported AlCl3-catalyzed rearrangement of 1-(4-ethoxyphenyl)-2,2-dimehtylpropan-1-one, followed by
Facile synthesis of 3-(p-alkoxyphenyl)-3-methyl-2-butanones
Gopalakrishnan,Anandhi
, p. 2521 - 2528 (2007/10/02)
A novel procedure for the preparation of 3-(p-hydroxyphenyl)-3-methyl-2-butanone, in excellent yield, is described via a simple AlCl3 catalysed rearrangement of p-ethoxy-pivalophenone. Various 3-(p-alkoxyphenyl)-3-methyl-2-butanones have been s
Certain aryl-alkane-2-pyridyloxy-phenyl derivatives having insecticidal and acaricidal activity
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, (2008/06/13)
The present invention relates to novel aromatic alkane derivatives represented by the following general formula (I): STR1 wherein Ar stands for a substituted or unsubstituted phenyl or naphthyl group, R1 stands for a methyl, ethyl or isopropyl group and R2 stands for a hydrogen atom or a methyl group, or R1 and R2 together with the carbon to which they are attached jointly represent a substituted or unsubstituted cycloalkyl group and R3, stands for a fundamental group of an alcohol which is usually used in a form of R3 OH as to natural or synthetic pyrethroids, and also to the uses of these compounds. These compounds of the present invention have excellent insecticidal and acaricidal activities while the toxicities of these compounds are very low.