1496-35-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Fluorophenyl)cyclohexanol is used as a building block in the synthesis of various medicinal products for its unique chemical structure and properties. It contributes to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1-(3-Fluorophenyl)cyclohexanol is used as a building block in the synthesis of agricultural products, such as pesticides and herbicides, due to its potential biological activities and unique chemical structure.
Used in Production of Synthetic Organic Compounds:
1-(3-Fluorophenyl)cyclohexanol is used as a key intermediate in the production of synthetic organic compounds, enabling the creation of a wide range of chemical products with diverse applications.
Used in Scientific Research:
1-(3-Fluorophenyl)cyclohexanol is a subject of scientific research for its potential therapeutic uses and biological activities, exploring its applications in various fields, including medicine and agriculture.

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 108-94-1 cyclohexanone 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 

Downstream Products

• 455-38-9 3-fluorobenzoic acid 
• 1717-83-5 1-cyclohexyl-3-fluorobenzene 
• 125827-86-3 1-(3-fluorophenyl)cyclohexanamine 
• 1546-10-7 1-cyclohex-1-en-1-yl-3-fluorobenzene 

Relevant academic research and scientific papers

The Barbier-Grignard-Type Arylation of Ketones and Unexpected Cross-Coupling of Phenolic Ketones using Unactivated Aryl Bromides

A novel, highly versatile and efficient method has been developed for the Barbier-Grignard-type arylation of ketones and an unexpected cross-coupling of phenolic ketones was observed using unactivated bromides and magnesium in tetrahydrofuran/toluene at 96°C promoted by multicatalysts of cupric bromide (15 mol%), bismuth chloride (5 mol%) and silver bromide (10 mol%). The substituent and electronic effects on the reaction have been discussed. High yields of arylation and cross-coupling have been attained under mild conditions. A novel reasonable mechanism involving a quinone intermediate is proposed. The high chemical selectivity in the cross-coupling to the hydroxy group of phenolic ketones should help ketones find new applications.

Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.