149690-05-1

Basic information

• Product Name: Sacubitril Sodium Salt
• Synonyms: Sacubitril Sodium Salt;Sacubitril sodium
• CAS NO: 149690-05-1
• Molecular Formula: C₂₄H₂₈NO₅*Na
• Molecular Weight: 433.47259
• Mol File: 149690-05-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C, Hygroscopic
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Sacubitril Sodium Salt(CAS DataBase Reference)
• NIST Chemistry Reference: Sacubitril Sodium Salt(149690-05-1)
• EPA Substance Registry System: Sacubitril Sodium Salt(149690-05-1)

Safety Data

• Hazardous Substances Data: 149690-05-1(Hazardous Substances Data)

Usage

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Upstream product

• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 
• 108-30-5 succinic acid anhydride 
• 149709-56-8 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-D-tyrosinate 
• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 149709-60-4 ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate 
• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 1038924-97-8 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate 

Downstream Products

• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 

Relevant articles and documents

AMMONIUM CARBOXYLATE COMPOUND, CRYSTALLINE FORM, AMORPHOUS FORM AND PREPARATION METHOD THEREOF

The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

AMORPHOUS TRISODIUM SACUBITRIL VALSARTAN AND PROCESS FOR ITS PREPARATION

The present invention provides for crystalline Form B1 of N-(3-carboxyl-1-oxopropyl)- (4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, crystalline Form B2 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4- amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4- amino-2R-methyl butanoic acid ethyl ester sodium salt. The present invention also provides for crystalline Form B of (S)-N-(1 -Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2'-(1 H- Tetrazol-5-yl)-Biphenyl-4-yl-Methyl]-Amine disodium salt, crystalline Form P of (S)-N- (1 -Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2'-(1 H-Tetrazol-5-yl)-Biphenyl-4-yl- Methyl]-Amine disodium salt and processes for their preparation thereof. The present invention further provides an industrial method production of Amorphous Form of Sacubitril valsartan trisodium. The present invention also provides for amorphous solid dispersions of Sacubitril valsartan trisodium with excipients.

Sacubitril sodium salt, eutectic mixture of sacubitril free acid and acetic acid, crystal form of eutectic mixture, and preparation method and use of crystal form

The invention relates to sacubitril sodium salt shown in a formula (IV), a eutectic mixture of sacubitril free acid and acetic acid, a crystal form of the eutectic mixture, a preparation method of thecrystal form, and a method for preparing LCZ696 by using the eutectic mixture with the crystal form. The eutectic mixture provided by the invention can form the stable crystal form, and does not easily absorb moisture; the eutectic mixture is better in thermal stability, convenient for purification of sacubitril, convenient to store and beneficial to synthesis of LCZ696. Furthermore, the eutecticmixture provided by the invention can be directly used for preparing the LCZ696 without needing additional ion exchange, and helps to control the type and content of the counter cations.