149771-44-8Relevant academic research and scientific papers
Multi-purpose diazabicyclo compound, preparation method and application thereof in synthetic drugs
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Paragraph 0052-0058, (2021/11/27)
The invention provides a multi-purpose diazabicyclo compound, a preparation method and an application thereof in synthesis of drugs, and belongs to the field of organic synthesis. The invention provides the multi-purpose diazabicyclo compound, the structural formula of which is as shown in formula 1: in the formula, R is any one of 2-nitrobenzenesulfonyl, 4-nitrobenzenesulfonyl or 2, 4-dinitrobenzenesulfonyl. According to the multipurpose diazabicyclo compound disclosed by the invention, two nitrogen atoms respectively have two different protecting groups, and the removing methods of the two protecting groups are different, so that the other protecting group is not influenced in the process of removing one protecting group, and therefore, the multipurpose diazabicyclo compound can be used for removing the other protecting group. The diazabicyclo compound provided by the invention is a multipurpose intermediate which can be applied to synthesis of various drugs.
Pyruvate kinase activators for use in therapy
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, (2016/08/29)
Described herein are methods for using compounds that activate pyruvate kinase.
NOVEL SUBSTITUTED DIAZABICYCLO DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
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Page/Page column 16, (2008/06/13)
This invention relates to novel substituted diazabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions
Substituted diazabicycloakane derivatives
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Page/Page column 18, (2010/02/11)
Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
Substituted diazabicycloalkane derivatives
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Page/Page column 26, (2010/02/11)
Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
Novel amides useful for treating pain
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Page/Page column 15, (2010/02/10)
The present invention relates to compounds of formula (I) that useful in treating pain.
Novel amides useful for treating pain
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Page/Page column 17, (2010/02/11)
The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.
3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias
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, (2008/06/13)
There is provided compounds of formula (I), wherein R1, R2 and Ra to Rb have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and v
Tandem cyclisation and [2,3]-Stevens rearrangement to 2-substituted pyrrolidines
Smith, Stephen C,Bentley, Philip D
, p. 899 - 902 (2007/10/03)
Reaction of N-methylallylamine with diethyl meso-2,5-dibromoadipate in DMF at ambient temperature in the presence of potassium carbonate led directly to the two diastereomers of diethyl 2-allyl-N-methylpyrrolidine-2,5-dicarboxylate. The reaction proceeds via a [2,3]-sigmatropic Stevens rearrangement, which occurred spontaneously under the reaction conditions. This gave a higher yield under milder conditions than the traditional Stevens reaction of diethyl N-allylpyrrolidine-2,5-dicarboxylate with iodomethane. The sequence was a key step in the synthesis of a series of analogues of the alkaloid stemofoline.
N-benzenesulfonyl l-proline compounds as bradykinin antagonists
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, (2008/06/13)
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein X1 and X2 are halo; R1 and R2 are independently hydrogen or C1-4 alkyl; R3 and R4 are each hydrogen or halo; and R5 is (a) —C3-9 diazacycloalkyl optionally substituted with C5-11 azabicycloalkyl; (b) —C3-9 azacycloalkyl-NH—(C5-11 azabicycloalkyl optionally substituted with C1-4 alkyl); (c) —NH—C1-3 alkyl-C(O)—C5-11 diazabicycloalkyl; (d) —NH—C1-3 alkyl-C(O)—NH—C5-11 azabicycloalkyl, the C5-11 azabicycloalkyl being optionally substituted with C1-4 alkyl; (e) —C3-9 azacycloalkyl optionally substituted with C3-9 azacycloalkyl; or (f) —NH—C1-5 alkyl-NH—C(O)—C4-9 cycloalkyl-NH2. These compounds are useful for the treatment of medical conditions mediated by bradykinin such as inflammation, allergic rhinitis, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.
