149771-44-8Relevant articles and documents
Multi-purpose diazabicyclo compound, preparation method and application thereof in synthetic drugs
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Paragraph 0052-0058, (2021/11/27)
The invention provides a multi-purpose diazabicyclo compound, a preparation method and an application thereof in synthesis of drugs, and belongs to the field of organic synthesis. The invention provides the multi-purpose diazabicyclo compound, the structural formula of which is as shown in formula 1: in the formula, R is any one of 2-nitrobenzenesulfonyl, 4-nitrobenzenesulfonyl or 2, 4-dinitrobenzenesulfonyl. According to the multipurpose diazabicyclo compound disclosed by the invention, two nitrogen atoms respectively have two different protecting groups, and the removing methods of the two protecting groups are different, so that the other protecting group is not influenced in the process of removing one protecting group, and therefore, the multipurpose diazabicyclo compound can be used for removing the other protecting group. The diazabicyclo compound provided by the invention is a multipurpose intermediate which can be applied to synthesis of various drugs.
NOVEL SUBSTITUTED DIAZABICYCLO DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
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, (2008/06/13)
This invention relates to novel substituted diazabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions
Substituted diazabicycloalkane derivatives
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Page/Page column 26, (2010/02/11)
Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.