1498-65-3

Upstream product

• 683-85-2 N,N-dimethylaminodichlorophosphane 
• 506-59-2 N,N-dimethylammonium chloride 
• 71-55-6 1,1,1-trichloroethane 
• 124-40-3 dimethyl amine 
• 677-43-0 N,N-dimethylphosphoroamidic dichloride 

Downstream Products

• 28167-51-3 N,N-dimethyl O,O-dimethyl phosphoramidothioate 
• 95980-94-2 dimethyl-amidothiophosphoric acid O-ethyl ester-O'-(4-chloro-phenyl ester) 
• 94406-57-2 dimethyl-amidothiophosphoric acid O-ethyl ester-O'-(2,4,5-trichloro-phenyl ester) 
• 100869-48-5 dimethyl-amidothiophosphoric acid O,O'-bis-(4-chloro-phenyl ester) 
• 57858-66-9 N,N-dimethyl-N',N''-diphenyl-thiophosphamide 
• 812-13-5 Difluorthiophosphorsaeure-dimethylamid 
• 81581-16-0 (2R,4R,5S)-2-dimethylamino-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione 
• 1778-99-0 Thiophosphorsaeure-O,O-bis-pentachlorphenylester-dimethylamid 

Relevant academic research and scientific papers

Linear synthesis of chiral cycloSal-pronucleotides

CycloSal-nucleosyl-phosphate triesters are a known class of highly effective nucleotide prodrugs (pronucleotides) of antivirally active nucleoside analogues. Until recently, the synthesis of these compounds always gave diastereoisomeric mixtures. Then, a convergent route for the stereospecific synthesis of cycloSal-triesters was described to give isomerically pure cycloSal-prodrugs for the treatment of viral diseases. Here, the development of a stereoselective synthesis of these pronucleotides using various chiral auxiliaries is described. In contrast to pyrrolidine- or pyrrolidinone derivatives it was found that a thiazolidine derived from valinol fulfilled all three requirements to act as a suitable chiral moiety, allowing: (i) strong chirality transfer, (ii) the formation of separable diastereoisomeric intermediates, and (iii) a suitable leaving group that allows the introduction of the nucleoside analogue (e.g., d4T) in the final step under mild reaction conditions. The title compounds were obtained with very high diastereoisomeric excesses of more than 95%. The development of a stereoselective route to cycloSal-nucleotides of thymidine and d4T based on the use of various chiral auxiliaries is reported. The target chiralphosphates were obtained with very high diastereoisomeric excesses of more than 95%.

Synthesis of novel chiral 2-Oxo- And 2-thio-1,3,2-oxazaphospholidines via asymmetric cyclization of L-methionol with (thio)phosphoryl dichlorides

In order to search for novel antitumor and antiviral agents with high activity and low toxicity, a series of chiral 2-thio(oxo)-1,3,2- oxazaphospholidines were synthesized via the reaction of L-methionol with all kinds of (thio)phosphoryl dichlorides in THF in the presence of triethylamine at room temperature. The structures of all of the new compounds were confirmed by elemental analyses, 1H, 31P NMR, and 1R spectra.

Thionation of phosphoramidodichloridates and phosphoramidate diesters using phosphorus pentasulfide and hexamethyldisiloxane under microwave irradiation. Part 1

A new, mild, efficient, and solvent-free microwave promoted synthesis of thiophosphoramidodichloridates and thiophosphoramidate diesters is described. The thionation reaction was accelerated with microwave irradiation using the combination of P4S10 and HMDO. The conversion of PO to PS by this method gave the desired product in higher yields and shorter reaction times as compared to conventional methods.