1498-93-7

Upstream product

• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 65130-79-2 bis(2-chlorobenzyl)amine 
• 91543-76-9 C₂₁H₁₇ClN₂O₂ 
• 22776-96-1 2,4,6-Tris-(2-chloro-phenyl)-[1,3,5]dithiazinane 
• 91357-37-8 2,4-Bis-(2-chloro-phenyl)-6-methyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 
• 91357-41-4 2-((2-Chloro-phenyl)-{[1-(2-chloro-phenyl)-meth-(E)-ylidene]-amino}-methyl)-1,3-diphenyl-propane-1,3-dione 
• 91357-38-9 1-[2,4-Bis-(2-chloro-phenyl)-6-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethanone 
• 91357-31-2 1-[2,4-Bis-(2-chloro-phenyl)-6-methyl-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethanone 
• 165056-53-1 2,5-di(2-chlorophenyl)-3,3,4,4-tetracyanopyrrolidine 
• 98013-42-4 2,4,6-Tris<2-chlorophenyl>-1,3,5-triazabicyclo<3.1.0>hexane 
• 1498-37-9 2,4,5-tris(2-chlorophenyl)-1H-imidazole 

Relevant academic research and scientific papers

2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation

Imidazoline-based small molecule inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents

Adducts of Triallylborane with Ammonia and Aliphatic Amines as Stoichiometric Allylating Agents for Aminoallylation Reaction of Carbonyl Compounds

Triallylborane-amines adducts are effective stoichiometric allylating agents in the aminoallylation reaction of carbonyl compounds in methanol. Moreover, copper-catalyzed diastereoselective allylation of Ellman's imine was achieved with triallylborane-methylamine adduct.

Novel method for the synthesis of α-amino-α- hydroxyalkylphosphinic acids and bis(α-aminoalkyl)phosphinic acids: Nuclephilic addition of α-hydroxy-H-phosphinic acids to diimines

We report here a novel and simple method for the synthesis of α-amino-α-hydroxyalkylphosphinic acids in good yields in two simple steps without any protection-deprotection steps. We have developed an efficient method for the synthesis of α-amino-α-hydroxyalkylphosphinic acids via the reaction of easily available α-hydroxyalkylphosphinic acids with diimines. Treatment of α-hydroxyalkylphosphinic acids with diimines in the presence of trimethylsilyl chloride (TMSCl) gives α-amino-α- hydroxyalkylphosphinic acids in good yields. The reaction gave a mixture of two diastereomeric forms of α-amino-α-hydroxyalkylphosphinic acids. The difference in solubility in organic solvents allowed us to readily separate the diastereoisomers. Georg Thieme Verlag Stuttgart · New York.

Studies on the reaction of diimines with thiourea: Synthesis and solvent-induced cis/trans-isomerization of 1,3,5-triazinane-2-thiones

The reaction of N,Nc-bis(arylmethylidene)arylmethane diimines with thiourea under reflux in methanol was studied. The reaction gave a diastereomeric mixture of 4,6-disubstituted 1,3,5-triazinane-2-thiones in good yields. Two diastereoisomers of 4,6-diphenyl-1,3,5-triazinane-2-thione were detected in a solution of CDCl3 by NMR analysis. According to the NMR studies, the cisdiastereoisomer undergoes a solvent-induced cis/trans-isomerization process, producing the trans-diastereoisomer in DMSO. The stereochemistry of the trans-diastereoisomer was determined by Xray crystallographic analysis.