14983-65-4

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 1808-49-7 Diantipyryl-(4-methoxy-phenyl)-methan 

Relevant academic research and scientific papers

Reaction of ethyl N,N-(p-methoxybenzal)-p-aminobenzoate with dialkyl phosphonates

Interaction of ethyl N,N-(p-methoxybenzal)-p-aminobenzoate with dialkyl phosphonates results in dialkyl (N-p-ethoxycarbonylphenylamino)-p-methoxybenzyl phosphonates. In the resulting compounds hydrogen bonds are observed by IR spectroscopy.

Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline

A concise organocatalytic approach towards optically active 1,2,3-trisubstituted azetidines, including a study of the scope and limitations of the synthetic sequence, is reported. The synthesis comprises the one-pot L-proline promoted three-component reac

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.

Investigation of the substituent specific cross-interaction effects on 13C NMR of the C=N bridging group in substituted benzylidene anilines

The substituent effect on 13C NMR of the C=N in benzylidene anilines XPhCH=NPhY was investigated, in which the substituents X and Y are in p-position or in m-position of the two aromatic rings. The substituent effects including the inductive effects of X and Y, the conjugative effects of X and Y, and the substituent specific cross-interaction effect were put into one model to quantify the 13C NMR chemical shift δC(C=N) of the C=N in XPhCH=NPhY. A penta-parameter correlation equation with correlation coefficient 0.9975 and standard error 0.17 ppm was obtained for 80 samples of compounds. The result shows that the substituents X and Y have an opposite effect on the δC(C=N). The electron-withdrawing effects of X decrease the δC(C=N); while the electron-donating effects of X increase the δC(C=N). In contrast, the electron-withdrawing effects of Y increase the δC(C=N); while the electron-donating effects of Y decrease the δC(C=N). A new substituent specific cross-interaction effect parameter δσ2 was proposed, which indicates that the most substituent specific cross-interaction effect exists in the pair of max electron-withdrawing group (EWG) and max electron-donating group (EDG) or the pair of max EDG and max EWG. Further to verify the obtained correlation equation, 15 samples of model compounds were prepared and their δC(C=N) was measured in this work. The predicted δC(C=N) values with the obtained equation are in good agreement with the measured ones for these prepared compounds, which confirmed the reliability of the obtained equation.