149835-49-4

Basic information

• Product Name: 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol
• Synonyms: 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol
• CAS NO: 149835-49-4
• Molecular Weight: 512.687
• Mol File: 149835-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol(149835-49-4)
• EPA Substance Registry System: 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol(149835-49-4)

Safety Data

• Hazardous Substances Data: 149835-49-4(Hazardous Substances Data)

Upstream product

• 138109-49-6 2,4-dimethoxyphenylmagnesium bromide 
• 104068-77-1 3,3-[2,2-dimethyl-1,3-propanediylbis(oxy)]-5α,10α-epoxy-estr-9(11)-en-17β-ol 

Downstream Products

• 149279-80-1 11β-(2,4-dimethoxyphenyl)-3,3-<1,2-ethanediylbis(oxy)>estr-5(10)-en-17β-ol 
• 149279-78-7 11β-(2,4-dimethoxyphenyl)-17β-hydroxyestr-5(10)-en-3-one 
• 149835-51-8 11β-(2,4-dimethoxyphenyl)-17β-hydroxyestra-4,9-dien-3-one 

Relevant articles and documents

Synthesis of Oxygen-Bridged Antigestagens

A synthetic access to 10,11β-(oxy-1,2-phenylene)-steroids 13 is described.Key steps are the SN2' type introduction of suitably ortho substituted arenes into vinyl epoxide 4, and ring closure by an acid catalysed intramolecular epoxide opening with the corresponding phenol.The resulting oxygen bridged steroids 13 are transformed into pharmacologically relevant progesterone antagonists 19a-c and 20.Key Words: antigestagens; 11β-substituted steroids; 10,11β-(oxy-1,2-phenylene)-steroids; acid catalysed intramolecular epoxide opening