149838-35-7

Upstream product

• 149838-28-8 N-(tert-butoxycarbonyl)-γ-L-glutamyl-L-glutamic acid, α,α'-di-tert-butyl γ-methyl triester 
• 149838-29-9 (S)-5-(tert-butoxy)-4-((S)-5-(tert-butoxy)-4-((tert-butoxycarbonyl)amino)-5-oxopentanamido)-5-oxopentanoic acid 
• 149838-26-6 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan 
• 24277-38-1 (S)-(-)-1-tert-butyl-5-methyl-<(2-tert-butoxycarbonyl)amino>pentanedioate 
• 149838-25-5 p-<β-(((trimethylsilylethoxy)carbonyl)amino)ethyl>phenol 
• 24277-39-2 N-tert-butoxycarbonyl glutamic acid tert-butyl ester 
• 79640-72-5 L-glutamic acid 1-tert-butyl ester 5-methyl ester 
• 57732-63-5 1-tert-butyl 5-methyl (2S)-2-{[(benzyloxy)carbonyl]amino}pentanedioate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51-67-2 tyrosamine 
• 149838-27-7 3--5-(((tert-butoxycarbonyl)amino)methyl)furan 
• 149838-31-3 N-(tert-butoxycarbonyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamic acid, α,α',α'',α'''-tetra-tert-butyl γ-methyl pentaester 

Relevant academic research and scientific papers

Total synthesis of the methanogenic cofactors methanofuran and methanofuran b

Methanofuran, 3-[p-((N-(N″-((4R,5S)- or (4S,5A)-4,5,7-tricarboxyheptanoyl)-γL-glutamyl-γ-L-glutamyl)-β- amino)ethyl]phenoxymethyl}-5-(aminomethyl)furan, and methanofuran b, 3-{p-[(N-(-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L- glutamyl)-β-amino)ethyl]phenoxymethyl}-5-(aminomethyl)furan, are the first cofactors involved in the conversion of carbon dioxide to methane by the methanogenic bacteria Methanobacterium thermoautotrophicum and Methanosarcina barkeri, respectively. These two cofactors have now been synthesized, starting from glutamic acid, dimethyl glutarate, methyl 5-formyl-3-furoate, and tyramine. The synthetic compounds give the same NMR and mass spectra and biological activities as the natural cofactors.