149846-21-9

Upstream product

• 60463-77-6 1-methyl-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 56680-30-9 1-methyl-1,3-dihydro-3-<2-phenyl-2-oxoethylidene>-2H-indole-2-one 
• 91-56-5 indole-2,3-dione 
• 98-86-2 acetophenone 
• 149846-20-8 (E)-5,7-dichloro-1-methyl-2-oxoindolin-3-ylidene acetophenone 
• 106009-19-2 1-methyl-5,7-dichloroisatin 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 

Downstream Products

• 844-49-5 1-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 128316-88-1 3'-amino-2',5'-dihydro-1-methyl-6'-phenyl-2'-thioxospiro<3H-indole-3,4'(3'H)-pyrimidin>-2(1H)-one 
• 97100-26-0 2-Amino-4-(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-phenyl-furan-3-carboxylic acid ethyl ester 
• 97100-17-9 2-[1-(1-Methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-oxo-2-phenyl-ethyl]-malononitrile 
• 97100-22-6 2-Amino-4-[1-methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-5-phenyl-4,5-dihydro-furan-3-carbonitrile 
• 40526-76-9 1-methyl-5'-phenyl-2',4'-dihydrospiro[dihydroindole-3,3'-pyrazol]-2-one 
• 1374031-00-1 N-[(Z)-2-(1-methyl-2-oxoindolin-3-ylidene)-1-phenylethylidene]-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

New diastereoselective synthesis of 3-alkylidene-1-methyloxindoles

Addition of alkyl or aryl α-substituted acetophenones to N-methylisatin in basic media gives diastereomeric mixtures of the corresponding α-substituted 3-benzoylmethyl-3-hydroxy-1-methyloxindole in good yields. Under anhydrous conditions (concentrated sul

Spiro indolone compound as well as, preparation, method and pharmaceutical composition and application thereof

Spiro indolone compounds, a preparing method, a medicine composition and uses of the compounds are disclosed. In particular, the invention provide spiro indolone compounds shown as a formula I or II, a preparing method of the spiro indolone compounds and

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: Potential candidates for chemoprevention

Induction of cytoprotective phase 2 enzymes through inhibition of Keap1, a repressor of transcription factor Nrf2, is a cancer-prevention strategy. Compounds that elicit antiinflammatory and cytoprotective effects are promising candidates for chemoprevent

An easy Lewis acid-mediated isomerization from (E)- to (Z)-oxoindolin-3-ylidene ketones

(E)-2-Oxoindolin-3-ylidene ketones can be easily isomerized to their (Z)-isomers by AlCl3 at room temperature in CH2Cl2. The behaviour of the unsaturated dicarbonyl framework in the (Z)-configuration as a bidentate ligand

RETENTION OF THE CONFIGURATION OF OXOINDOLIN-3-YLIDENE DIPOLAROPHILES IN THE REACTION WITH AZOMETHINE YLIDES FROM NINHYDRIN AND SECONDARY AMINO ACIDS

The reaction of ninhydrin with sarcosin or proline gives azomethine ylides that can be trapped by (E)- or (Z)-oxoindolin-3-ylidene acetophenones. The configuration of the adducts can be assigned on the basis of NOE and Eu(fod)3 NMR experiments. The regiochemistry of the 1,3-dipolar cycloaddition is controlled by FMOs, while the configuration derives from the less hindered transition state. Under thermal conditions, some kinetically controlled products revert to dipole and dipolarophile that react to give the thermodynamically stable products.