844-49-5Relevant academic research and scientific papers
Synthesis of 1-Alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones through Gold/Bronsted Acid Relay Actions: Observation of Selective C=C Bond Cleavage of Enaminones
Zhao, Yulei,Yuan, Yang,Kong, Lingkai,Zhang, Fangfang,Li, Yanzhong
, p. 3609 - 3618 (2017/08/15)
A novel gold(I)/Bronsted acid sequential catalyzed/promoted procedure to synthesize 1-alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones under mild reaction conditions is developed. This methodology is realized by relay actions of gold and a Bronsted acid in a one-pot multistep manner. The gold(I)-catalyzed chemoselective C(sp 2)-H functionalization of enaminones and Bronsted acid promoted cleavage of the C=C bond are integrated effectively. Based on the results of control experiments and ESI-MS analysis, a possible reaction mechanism is proposed.
A Rhodium(II)-Catalyzed Formal [4+1]-Cycloaddition toward Spirooxindole Pyrrolone Construction Employing Vinyl Isocyanates as 1,4-Dipoles
Meloche, Jennifer L.,Ashfeld, Brandon L.
supporting information, p. 6604 - 6608 (2017/05/29)
A RhII-catalyzed, formal [4+1]-cycloaddition between diazooxindoles as electrophilic C1 synthons and 1,3-heterodienes for the construction of spirooxindole pyrrolones is described. Employing vinyl isocyanates as 1,4-dipoles, the cycloannulation occurs under relatively mild conditions and provides the corresponding pyrrolones in good to excellent yields.
Use of reductive properties of iodotrichlorosilane II: Chemoselective reduction of α,β-unsaturated ketones and nitriles
Elmorsy, Saad S.,El-Ahl, Abdel-Aziz S.,Soliman, Hanan,Amer, Fathy A.
, p. 2297 - 2298 (2007/10/03)
A new synthetic procedure for the selective reduction of α,β-unsaturated ketones and nitriles, using iodotrichlorosilane (ITCS generated in situ from SiCl4-NaI) under mild conditions to produce the corresponding saturated ketone and nitrile compounds in quantitative yields, is described.
